ArticleJournal of bacteriology2012
Rethinking the evolution of single-stranded RNA (ssRNA) bacteriophages based on genomic sequences and characterizations of two R-plasmid-dependent ssRNA phages, C-1 and Hgal1.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The cryo-EM structure of bacteriophage PRR1 and its role in conjugation inhibition.Journal of virology · 2026Article
- ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families.Protein science : a publication of the Protein Society · 2026Article
- Physiological characterization of single-gene lysis proteins.Journal of bacteriology · 2024Article
- Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages.Microorganisms · 2021Article
- Rapid de novo evolution of lysis genes in single-stranded RNA phages.Nature communications · 2020Article
- ssRNA phage penetration triggers detachment of the F-pilus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Single-gene lysis in the metagenomic era.Current opinion in microbiology · 2020Review
- Expansion of known ssRNA phage genomes: From tens to over a thousand.Science advances · 2020Article
- Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data.Journal of nanobiotechnology · 2019Article
- Phage single-gene lysis: Finding the weak spot in the bacterial cell wall.The Journal of biological chemistry · 2019Review
- A Pilin Region Affecting Host Range of theFrontiers in microbiology · 2018Article
- Mutational analysis of the MS2 lysis protein L.Microbiology (Reading, England) · 2017Article
- Hyperexpansion of RNA Bacteriophage Diversity.PLoS biology · 2016Article
- Diversity of pili-specific bacteriophages: genome sequence of IncM plasmid-dependent RNA phage M.BMC microbiology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have sequenced and characterized two R-plasmid-dependent single-stranded RNA bacteriophages (RPD ssRNA phages), C-1 and Hagl1. Phage C-1 requires a conjugative plasmid of the IncC group, while Hgal1 requires the IncH group. Both the adsorption rate constants and one-step growth curves are determined for both phages. We also empirically confirmed the lysis function of the predicted lysis genes. Genomic sequencing and phylogenetic analyses showed that both phages belong to the Levivirus group and are most closely related to another IncP-plasmid-dependent ssRNA phage, PRR1. Furthermore, our result strongly suggests that the stereotypical bauplans of genome organization found in Levivirus and Allolevivirus predate phage specialization for conjugative plasmids, suggesting that the utilization of conjugative plasmids for cell attachment and entry comprises independent evolutionary events for these two main clades of ssRNA phages. Our result is also consistent with findings of a previous study, making the Levivirus-like genome organization ancestral and the Allolevivirus-like genome derived. To obtain a deeper insight into the evolution of ssRNA phages, more phages specializing for various conjugative plasmids and infecting different bacterial species would be needed.
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