ArticlePathology oncology research : POR2013
Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9.
Article in Pathology oncology research : POR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Investigation of the Mechanism ofInternational journal of general medicine · 2024Article
- Article
- MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non-cancerous tissues.Oncology letters · 2021Article
- Evaluation of Important Molecular Pathways and Candidate Diagnostic Biomarkers of Noninvasive to Invasive Stages in Gastric Cancer by In Silico Analysis.Journal of oncology · 2021Article
- Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells.International journal of oncology · 2020Article
- Multifaceted Functional Role of Semaphorins in Glioblastoma.International journal of molecular sciences · 2019Review
- Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis.Oncotarget · 2018Article
- The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer.Cancer cell international · 2018Article
- The role of the semaphorins in cancer.Cell adhesion & migration · 2016Review
- Transmembrane semaphorins, forward and reverse signaling: have a look both ways.Cellular and molecular life sciences : CMLS · 2016Review
- Pathway crosstalk analysis of microarray gene expression profile in human hepatocellular carcinoma.Pathology oncology research : POR · 2015Article
- Loss of plexin-B3 in hepatocellular carcinoma.Experimental and therapeutic medicine · 2015Article
- Semaphorin 5A mediated cellular navigation: connecting nervous system and cancer.Biochimica et biophysica acta · 2014Review
- Microarray expression profile analysis of long non-coding RNAs of advanced stage human gastric cardia adenocarcinoma.Molecular genetics and genomics : MGG · 2014Article
- Semaphorin 5A promotes gastric cancer invasion/metastasis via urokinase-type plasminogen activator/phosphoinositide 3-kinase/protein kinase B.Digestive diseases and sciences · 2013Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semaphorin 5A, a member of semaphorin family, was originally identified as axonal guidance factor functioning during neuronal development. Previously, we showed that the expression of semaphorin 5A might contribute to the metastasis of gastric cancer. However, its functional roles and mechanism(s) in invasion and metastasis of gastric cancer remain unclear. By using human gastric caner cell lines Parental SGC7901, SGC7901-siScrambled and SGC7901-siSema 5A, we found that semaphorin 5A significantly promoted the invasive and metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased the expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell. Furthermore, MEK inhibitor PD98059 and MMP9 antibody (Ab) significantly inhibited in vitro invasive and metastatic abilities induced by semaphorin 5A. Taken together, the present work revealed a novel function of semaphorin 5A that the existence of semaphorin 5A could promote invasion and metastasis of gastric cancer by regulating MMP9 expression, at least partially, via the MEK/ERKs signal transduction pathway. Semaphorin 5A and its regulated molecules could be the potential targets for cancer therapy.
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