ArticleThe European physical journal. E, Soft matter2012
Optical trapping microrheology in cultured human cells.
Article in The European physical journal. E, Soft matter, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- High-frequency micro-viscoelasticity of biofluids by using optical trapping interferometry.Biophysical reviews · 2026Review
- Determination of the Minimum Cell-to-Cell Adhesion Time Using Optical Tweezers in Leukemia and Lymphoma Research.Methods and protocols · 2025Article
- Passive and Active Microrheology for Biomedical Systems.Frontiers in bioengineering and biotechnology · 2022Review
- Multi-oscillation microrheologyLab on a chip · 2021Article
- A constriction channel analysis of astrocytoma stiffness and disease progression.Biomicrofluidics · 2021Article
- Nanometer optical trap based on stimulated emission in evanescence of a totally reflected Arago spot : Nanometer optical trap for fluorescent nanoparticles.The European physical journal. E, Soft matter · 2020Article
- Heterogeneities Shape Passive Intracellular Transport.Biophysical journal · 2019Article
- Fluid heterogeneity detection based on the asymptotic distribution of the time-averaged mean squared displacement in single particle tracking experiments.Journal of physics. A, Mathematical and theoretical · 2018Article
- Diffusion-limited reactions in dynamic heterogeneous media.Nature communications · 2018Article
- Sensing Magnetic Fields with Magnetosensitive Ion Channels.Sensors (Basel, Switzerland) · 2018Article
- High-frequency microrheology reveals cytoskeleton dynamics in living cells.Nature physics · 2017Article
- Surface-modified complex SU-8 microstructures for indirect optical manipulation of single cells.Biomedical optics express · 2016Article
- Mechanical properties of normal versus cancerous breast cells.Biomechanics and modeling in mechanobiology · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the microrheological study of the two close human epithelial cell lines: non-cancerous HCV29 and cancerous T24. The optical tweezers tracking was applied to extract the several seconds long trajectories of endogenous lipid granules at time step of 1μs. They were analyzed using a recently proposed equation for mean square displacement (MSD) in the case of subdiffusion influenced by an optical trap. This equation leads to an explicit form for viscoelastic moduli. The moduli of the two cell lines were found to be the same within the experimental accuracy for frequencies 10(2) - 10(5) Hz. For both cell lines subdiffusion was observed with the exponent close to 3/4, the value predicted by the theory of semiflexible polymers. For times longer than 0.1s the MSD of cancerous cells exceeds the MSD of non-cancerous cells for all values of the trapping force. Such behavior can be interpreted as a signature of the active processes and prevents the extraction of the low-frequency viscoelastic moduli for the living cells by passive microrheology.
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