ArticleCell stress & chaperones2013
Heat shock protein production and immunity and altered fetal development in diabetic pregnant rats.
Article in Cell stress & chaperones, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Skeletal malformations and growth disturbances in fetuses of mild diabetic ratsBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2020Article
- [Effect of heat exposure in the second trimester of pregnancy on intrauterine growth of fatal rat and the expression of HSP70, Bax and Bcl-2 of placenta].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Hsp70 plays an important role in high-fat diet induced gestational hyperglycemia in mice.Journal of physiology and biochemistry · 2015Article
- Extracellular HSP70 levels in diabetic environment in rats.Cell stress & chaperones · 2015Article
- Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study.Cell stress & chaperones · 2015Article
- Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes.BioMed research international · 2014Review
- Neonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats.Diabetology & metabolic syndrome · 2013Article
- Induction of the 72 kDa heat shock protein by glucose ingestion in black pregnant women.Cell stress & chaperones · 2013Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated associations between the concentrations of heat shock proteins (hsp60 and hsp70) and their respective antibodies, alterations in maternal reproductive performance, and fetal malformations in pregnant rats with hyperglycemia. Mild diabetes (MD) or severe diabetes (SD) was induced in Sprague-Dawley rats prior to mating; non-treated non-diabetic rats (ND) served as controls. On day 21 of pregnancy, maternal blood was analyzed for hsp60 and hsp70 and their antibodies; and fetuses were weighed and analyzed for congenital malformations. Hsp and anti-hsp levels were correlated with blood glucose levels during gestation. There was a positive correlation between hsp60 and hsp70 levels and the total number of malformations (R = 0.5908, P = 0.0024; R = 0.4877, P = 0.0134, respectively) and the number of malformations per fetus (R = 0.6103, P = 0.0015; R = 0.4875, P = 0.0134, respectively). The anti-hsp60 IgG concentration was correlated with the number of malformations per fetus (R = 0.3887, P = 0.0451) and the anti-hsp70 IgG level correlated with the total number of malformations (R = 0.3999, P = 0.0387). Moreover, both hsp and anti-hsp antibodies showed negative correlations with fetal weight. The results suggest that there is a relationship between hsp60 and hsp70 levels and their respective antibodies and alterations in maternal reproductive performance and impaired fetal development and growth in pregnancies associated with diabetes.
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