ArticleClinical research in cardiology : official journal of the German Cardiac Society2013
Left cardiac sympathetic denervation for the management of life-threatening ventricular tachyarrhythmias in young patients with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Neural Regulation of Cardiac Arrhythmias: From the Brain-Heart Axis to Emerging Precision Therapies.Research (Washington, D.C.) · 2026Review
- Article
- Stellate Ganglia and Cardiac Sympathetic Overactivation in Heart Failure.International journal of molecular sciences · 2022Review
- One family's clinical odyssey from evolving phenotypic and genotypic knowledge of catecholaminergic polymorphic ventricular tachycardia and long QT syndrome.HeartRhythm case reports · 2022Article
- Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives.Pharmaceutics · 2022Review
- Pooled Analysis of Complications with Transvenous ICD Compared to Subcutaneous ICD in Patients with Catecholaminergic Polymorphic Ventricular Arrhythmia.Journal of personalized medicine · 2022Article
- JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias.Journal of arrhythmia · 2021Article
- Neuromodulation Therapy in Heart Failure: Combined Use of Drugs and Devices.The Journal of innovations in cardiac rhythm management · 2020Article
- Bilateral sympathetic stellate ganglionectomy attenuates myocardial remodelling and fibrosis in a rat model of chronic volume overload.Journal of cellular and molecular medicine · 2019Article
- Autonomic Neuromodulation for Preventing and Treating Ventricular Arrhythmias.Frontiers in physiology · 2019Review
- Substrates and potential therapeutics of ventricular arrhythmias in heart failure.European journal of pharmacology · 2018Review
- Selective ablation of the ligament of Marshall reduces ischemia and reperfusion-induced ventricular arrhythmias.PloS one · 2018Article
- Therapeutic Strategies Targeting Inherited Cardiomyopathies.Current heart failure reports · 2017Review
- Left cardiac sympathetic denervation: case series and technical report.Irish journal of medical science · 2017Article
- Left cardiac sympathetic denervation: An important treatment option for patients with hereditary ventricular arrhythmias.Journal of arrhythmia · 2016Review
- Association between ventricular arrhythmias and myocardial mechanical dispersion assessed by strain analysis in patients with nonischemic cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Renal sympathetic denervation for treatment of ventricular arrhythmias: a review on current experimental and clinical findings.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Review
- Rescue renal sympathetic denervation in a patient with ventricular electrical storm refractory to endo- and epicardial catheter ablation.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Sympathoneural and adrenomedullary responses to mental stress.Comprehensive Physiology · 2015Review
- Epicardial ablation cures electrical storm caused by cardiac involvement in myotonic dystrophia type 2.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
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6 authors.
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Abstract
backgroundLeft cardiac sympathetic denervation (LCSD) may be a therapeutic adjunct for young patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and long QT syndrome (LQTS) who are not fully protected by beta-blockade.
objectiveThe objective of this analysis was to report our institutional experience with LSCD in young patients for the management of life-threatening ventricular arrhythmias in CPVT and LQTS.
methodsTen young patients with CPVT and LQTS underwent transaxillary LSCD at our institution. Mean age at surgery was 14.0 (range 3.9-42) years, mean body weight was 45.7 (range 15.5-90) kg. Five patients had the clinical diagnosis of CPVT, three were genotype positive for a mutation in the ryanodine-receptor-2-gene. Four of five LQTS patients were genotype positive. Indications for LCSD were recurrent syncope, symptomatic episodes of ventricular tachycardias and/or internal cardioverter-defibrillator (ICD) discharges, and aborted cardiac arrest despite high doses of beta-blockers.
resultsLCSD was performed via the transaxillary approach. No significant complications were observed. Two patients already had an ICD, 6 patients received an ICD at the same operation or shortly thereafter. Median length of follow-up after LCSD was 2.3 (range 0.6-3.9) years. After LCSD a marked reduction in arrhythmia burden and cardiac events was observed in all patients while medication was continued. None of the patients had any further ICD discharge for sustained VT.
conclusionsAfter LCSD, arrhythmia burden could significantly be reduced in all our young patients with CPVT and LQTS.
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