Evidence map›Paper›PMID 22820962›Full record

ReviewAdvances in skin & wound care2012

Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery.

Tatiana N Demidova-Rice, Michael R Hamblin, Ira M Herman

Abstract readReview
In one paragraph

Review in Advances in skin & wound care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Black Sea-Derived Biomaterials for Wound-Healing Applications.International journal of molecular sciences · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Skin-on-chip: Quo vadis?APL bioengineering · 2025
    Review
  16. Article
  17. Article
  18. Efficacy of TopicalLaryngoscope investigative otolaryngology · 2025
    Article
  19. Review
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tatiana N Demidova-RiceTufts University School of Medicine, Boston, Massachusetts, USA.
Michael R Hamblin
Ira M Herman

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
NIAID NIH HHS R01 AI050875
6 · The paper itself

Abstract

This is the second of 2 articles that discuss the biology and pathophysiology of wound healing, reviewing the role that growth factors play in this process and describing the current methods for growth factor delivery into the wound bed.

Indexed as

Wound HealingAcute DiseaseDrug Delivery SystemsEpidermal Growth FactorHumansIntercellular Signaling Peptides and ProteinsPlatelet-Derived Growth FactorSignal TransductionTreatment FailureVascular Endothelial Growth Factor AWounds and InjuriesEpidermal Growth FactorIntercellular Signaling Peptides and ProteinsPlatelet-Derived Growth FactorVascular Endothelial Growth Factor A

Identifiers

PMID22820962
PMCPMC3426909

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.