SynthesisPediatric surgery international2012
Severe hyperphosphatemia after administration of sodium-phosphate containing laxatives in children: case series and systematic review of literature.
Synthesis in Pediatric surgery international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 49 citations in OpenAlex.
- Acute severe hyperphosphatemia and secondary hypocalcemia after phosphate enema administration in a constipated post-trauma patient recovering from pelvic surgery: a case report.Journal of surgical case reports · 2026Article
- Iatrogenic neonatal hyperphosphatemia due to phosphate-containing enema.Endocrinology, diabetes & metabolism case reports · 2025Article
- The Risks of Phosphate Enemas in Toddlers: A Life-Threatening Unawareness.Children (Basel, Switzerland) · 2024Article
- State of the Art Bowel Management for Pediatric Colorectal Problems: Spinal Anomalies.Children (Basel, Switzerland) · 2023Review
- What is the Evidence for Over the Counter Laxatives to Treat Childhood Constipation?Current gastroenterology reports · 2021Review
- Management Approach of Pediatric Constipation.Cureus · 2021Review
- Prolonged Seizure Activity Followed by Severe Hyperphosphatemia and Hypocalcemia in a Pediatric Patient.Cureus · 2021Article
- Functional constipation in children: challenges and solutions.Pediatric health, medicine and therapeutics · 2017Review
- Medical and Nonstroke Neurologic Causes of Acute, Continuous Vestibular Symptoms.Neurologic clinics · 2015Review
- A novel case of homozygous PAX1 mutation associated with hypoparathyroidism.Therapeutic advances in rare diseaseArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSodium phosphate-containing laxatives are commonly used as first-line treatment option for constipation in children and adolescents. Hyperphosphatemia is an infrequent, but potentially life-threatening complication of laxative application.
methodsWe report a case series of three children exhibiting severe hyperphosphatemia and hypocalcemia after utilization of sodium phosphate-containing laxatives, necessitating intensive care services in two of three cases. Additionally, we reviewed 32 case reports of similar occurrences.
resultsWe identified 28 publications on the subject dating from 1968 to 2010. Mean age of all children in reports was 2.83 years; sex was approximately equally distributed. While 18 patients suffered from either pre-existing gastrointestinal comorbidity or other major systemic disease, no or only unrelated, minor conditions were present in ten children. One-third of patients received laxatives repeatedly before the incident. Findings associated with hyperphosphatemia include lethargy, dizziness, stiffness, tachypnea, tachycardia and severe dehydration in almost all cases, and tetany, carpopedal spasm, and prolonged QT interval in a subset. While about 80% of children recovered without residual findings, three deceased and one incurred persistent hypoxic brain damage.
conclusionPhysicians should be alerted to the possibility of phosphate toxicity in children and adolescents treated with laxatives.
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