ArticleJournal of acquired immune deficiency syndromes (1999)2012
Changes in the soluble mucosal immune environment during genital herpes outbreaks.
Article in Journal of acquired immune deficiency syndromes (1999), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Pre-exposure prophylaxis differentially alters circulating and mucosal immune cell activation in herpes simplex virus type 2 seropositive women.AIDS (London, England) · 2019Trial
- Cervicovaginal Secretions in Young Women With Bacterial Vaginosis Enhance HIV Infection.The Journal of infectious diseases · 2025Article
- No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study.Frontiers in immunology · 2025Article
- A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals.Scientific reports · 2021Article
- Establishment of a Novel Porcine Model to Study the Impact of Active Stretching on a Local Carrageenan-Induced Inflammation.American journal of physical medicine & rehabilitation · 2020Article
- Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity.NPJ vaccines · 2020Article
- Impact of Herpes Simplex Virus Type 2 and Human Immunodeficiency Virus Dual Infection on Female Genital Tract Mucosal Immunity and the Vaginal Microbiome.The Journal of infectious diseases · 2019Article
- Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection.PloS one · 2019Article
- Association of vaginal dysbiosis and biofilm with contraceptive vaginal ring biomass in African women.PloS one · 2017Article
- Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- The Effects of Hormones and Vaginal Microflora on the Glycome of the Female Genital Tract: Cervical-Vaginal Fluid.PloS one · 2016Article
- IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells.Frontiers in microbiology · 2016Article
- Cross-Sectional Analysis of Selected Genital Tract Immunological Markers and Molecular Vaginal Microbiota in Sub-Saharan African Women, with Relevance to HIV Risk and Prevention.Clinical and vaccine immunology : CVI · 2015Article
- Persistence of mucosal T-cell responses to herpes simplex virus type 2 in the female genital tract.Mucosal immunology · 2015Article
- Article
- HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infection.PLoS pathogens · 2014Article
- Research gaps in defining the biological link between HIV risk and hormonal contraception.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Review
- Antiviral activity of genital tract secretions after oral or topical tenofovir pre-exposure prophylaxis for HIV-1.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Article
- Plasma and mucosal HIV viral loads are associated with genital tract inflammation in HIV-infected women.Journal of acquired immune deficiency syndromes (1999) · 2013Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundGenital tract secretions provide variable inhibitory activity against herpes simplex virus (HSV) ex vivo. We hypothesize that the anti-HSV activity may prevent the spread of virus from the more commonly affected sites, such as the external genitalia, to the upper genital tract.
methodsThe antimicrobial activity of cervicovaginal lavage (CVL) and concentrations of mucosal immune mediators were measured in 10 HIV-seronegative women with an active external herpetic lesion and compared with 10 HIV-seronegative women who were HSV-1 and HSV-2 seronegative. Samples were obtained at the time of a symptomatic external lesion (day 0), after 1 week of oral acyclovir (day 7), and 1 week after completing treatment (day 14). Controls were evaluated at parallel intervals.
resultsThe anti-HSV activity was higher in CVL obtained from cases compared to controls at presentation (day 0) (54.3% vs. 28%), fell to similar levels on day 7, and then rebounded on day 14 (69% vs. 25%). The anti-HSV activity correlated positively and significantly with the concentrations of several inflammatory proteins; the concentrations of these proteins tended to be higher in cases compared with controls and followed a similar temporal pattern.
conclusionsIncreases in inflammatory immune mediators and anti-HSV activity were detected in CVL at the time of clinical outbreaks and after completion of a short course of acyclovir. These mucosal responses may protect against HSV spread but could facilitate HIV infection and contribute to the clinical observation that, independent of clinical lesions, HSV-2 is a risk factor for HIV acquisition.
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