ArticleJournal of neurology2013
Superficial siderosis is a warning sign for future intracranial hemorrhage.
Article in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Risk factors for recurrent cerebral amyloid angiopathy-related intracerebral hemorrhage.Frontiers in neurology · 2023Pooled it
- Research landscape and trends of cerebral amyloid angiopathy: a 25-year scientometric analysis.Frontiers in neurology · 2023Pooled it
- Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy: A meta-analysis.Neurology · 2019Pooled it
- Pooled it
- Cerebral Superficial Siderosis : Etiology, Neuroradiological Features and Clinical Findings.Clinical neuroradiology · 2023Review
- [Current findings on the coincidence of cerebral amyloid angiopathy and Alzheimer's disease].Der Nervenarzt · 2022Review
- Review
- CT-Visible Convexity Subarachnoid Hemorrhage is Associated With Cortical Superficial Siderosis and Predicts Recurrent ICH.Neurology · 2021Article
- Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy.Frontiers in aging neuroscience · 2021Article
- Early MRI imaging and follow-up study in cerebral amyloid angiopathy.Open medicine (Warsaw, Poland) · 2021Article
- Observational
- MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation.Neurology · 2019Observational
- An unusual presentation of superficial siderosis with focal dystonia and 'Giant panda morphology' on MRI: atypical clinicoradiological amalgam.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study.The Lancet. Neurology · 2018Observational
- Article
- Prevalence and clinical characteristics of cortical superficial siderosis in patients with acute stroke.Journal of neurology · 2017Article
- The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.Journal of neurology, neurosurgery, and psychiatry · 2017Review
- Hemorrhage recurrence risk factors in cerebral amyloid angiopathy: Comparative analysis of the overall small vessel disease severity score versus individual neuroimaging markers.Journal of the neurological sciences · 2017Article
- Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy.Neurology · 2017Article
- Small vessel disease burden in cerebral amyloid angiopathy without symptomatic hemorrhage.Neurology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supratentorial superficial siderosis (SS) is a frequent imaging marker of cerebral amyloid angiopathy (CAA). It is most probably caused by focal subarachnoid hemorrhages (fSAHs). Based on single-case observations, it has been proposed that such fSAHs might be a predisposing factor for future intracranial hemorrhage. Here we tested the hypothesis if a SS as a residue of fSAHs must be regarded as a warning sign for future intracranial hemorrhage. Fifty-one consecutive patients with SS and no apparent cause other than possible or probable CAA were identified through a database search and followed-up for a median interval of 35.3 months (range 6-120 months). Main outcome measures were rate and location of new intracranial hemorrhages. Twenty-four patients (47.1 %) had experienced any new intracranial hemorrhage, 18 patients (35.3 %) had an intracerebral hemorrhage (ICH), and in 13 of them (25.5 %), the hemorrhage was located at the site of pre-existing siderosis. Six patients (11.7 %) had developed a new subarachnoid hemorrhage (SAH), four of them at the site of siderosis. Patients with SS are at substantial risk for subsequent intracranial hemorrhage. SS can be considered a warning sign of future ICH or SAH, which frequently occur adjacent to pre-existing SS. Prospective studies are needed to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.