ArticleNature cell biology2012
Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses.
Article in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 439 papers.
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Who cites it
439 citing papers in PubMed.
- Antagonistic regulation of PIF4 and HY5 activity by BBX28 regulates thermomorphogenesis.Science advances · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brassinosteroids promote sugar synthesis by inhibiting BIN2 phosphorylation of phosphoenolpyruvate carboxykinase.Nature plants · 2026Article
- The VvBZR1-VvHY5 Module Integrates Brassinosteroid and Light Signaling to Regulate Anthocyanin Biosynthesis in Grape.Plant, cell & environment · 2026Article
- Shaping Plant Adaptation in a Warmer World: Developmental Plasticity Under Moderately Elevated Temperatures.Plants (Basel, Switzerland) · 2026Review
- Organ-on-a-Chip and Microfluidic Plant Cell Culture Systems: The Next Frontier for Controlled Secondary Metabolite Production and Real-Time Metabolomic Monitoring.Plants (Basel, Switzerland) · 2026Review
- The transcription elongation factor IWS1 promotes thermomorphogenesis by integrating the brassinosteroid and gibberellin pathways in Arabidopsis.Plant communications · 2026Article
- The BZR1-BLH1-PIF4 feedback module acts as a molecular amplifier for precise thermomorphogenesis in Arabidopsis.Nature communications · 2026Article
- Genome-Wide Identification and Expression Profiling of theInternational journal of molecular sciences · 2026Article
- Functional evolution and rewiring of the UVR8-BES1/BIM1 module underpin the refinement of UV-B responses during plant terrestrialization.Plant communications · 2026Article
- Comparative transcriptome analysis of sesame flower organs and potential functional analysis of the MIKC-MADS gene family.BMC genomics · 2026Article
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- Regulation of chloroplast biogenesis and differentiation.Journal of experimental botany · 2026Review
- CUL3Science advances · 2026Article
- Arabidopsis microtubule-BRI1-associated proteins negatively regulate hypocotyl elongation by controlling brassinosteroid-dependent cortical microtubule reorientation.Plant communications · 2026Article
- Far-Red Light Regulates the Circadian Rhythm Pathway to Accelerate Rice Flowering.International journal of molecular sciences · 2026Article
- Identification, characterization, and expression profiling of the bHLH gene family in Beta vulgaris.BMC plant biology · 2025Article
- Molecular Mechanisms of the Phytohormone-Heat Shock Protein Pathway in Regulating Plant Thermotolerance.Plants (Basel, Switzerland) · 2025Review
- Boron Toxicity Modulates Hypocotyl Growth Through Brassinosteroid and Thermomorphogenic-Like Mechanisms.Plant, cell & environment · 2025Article
- Single cis-elements in brassinosteroid-induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA-binding domain.FEBS letters · 2025Article
379 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Plant growth is coordinately regulated by environmental and hormonal signals. Brassinosteroid (BR) plays essential roles in growth regulation by light and temperature, but the interactions between BR and these environmental signals remain poorly understood at the molecular level. Here, we show that direct interaction between the dark- and heat-activated transcription factor phytochrome-interacting factor 4 (PIF4) and the BR-activated transcription factor BZR1 integrates the hormonal and environmental signals. BZR1 and PIF4 interact with each other in vitro and in vivo, bind to nearly 2,000 common target genes, and synergistically regulate many of these target genes, including the PRE family helix-loop-helix factors required for promoting cell elongation. Genetic analysis indicates that BZR1 and PIFs are interdependent in promoting cell elongation in response to BR, darkness or heat. These results show that the BZR1-PIF4 interaction controls a core transcription network, enabling plant growth co-regulation by the steroid and environmental signals.
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