Evidence map›Paper›PMID 22820325›Full record

ArticleApplied and environmental microbiology2012

Requirement of signal peptidase ComC and thiol-disulfide oxidoreductase DsbA for optimal cell surface display of pseudopilin ComGC in Staphylococcus aureus.

Magdalena M van der Kooi-Pol, Ewoud Reilman, Mark J J B Sibbald, Yanka K Veenstra-Kyuchukova, Thijs R H M Kouwen, Girbe Buist, Jan Maarten van Dijl

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. TMcin RiPP biosynthesis in the cellular membrane.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Disulfide bond formation in prokaryotes.Nature microbiology · 2018
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Magdalena M van der Kooi-PolDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Ewoud Reilman
Mark J J B Sibbald
Yanka K Veenstra-Kyuchukova
Thijs R H M Kouwen
Girbe Buist
Jan Maarten van Dijl

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.

Indexed as

Bacterial ProteinsGene ExpressionMembrane ProteinsProtein Disulfide Reductase (Glutathione)Serine EndopeptidasesStaphylococcus aureusBacterial ProteinsMembrane ProteinsProtein Disulfide Reductase (Glutathione)Serine Endopeptidasestype I signal peptidase

Identifiers

PMID22820325
PMCPMC3457507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.