ArticleNeurobiology of disease2012
Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors.
Article in Neurobiology of disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 3 of them syntheses that pooled it.
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Who cites it
98 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Mapping self-awareness of cancer-related cognitive impairment: a scoping review of evidence, methods, and neurobiological correlates.Frontiers in neurology · 2025Pooled it
- Prevalence of cognitive impairment and change in patients with breast cancer: A systematic review of longitudinal studies.Psycho-oncology · 2021Pooled it
- Cognitive Effects and Depression Associated With Taxane-Based Chemotherapy in Breast Cancer Survivors: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Cognitive impairment after chemotherapy related to atypical network architecture for executive control.Oncology · 2015Trial
- Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.Pediatric blood & cancer · 2014Trial
- Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.Clinical breast cancer · 2013Trial
- Trajectories of Cognitive Complaints in Patients With Breast Cancer and Their Association With Psychosocial and Neurobiological Factors.Cancer medicine · 2025Article
- Article
- Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Cancer-Related Cognitive Impairments (CRCIs) in Non-Central Nervous System Adult Patients: Outcome Measures and Methodology of Assessment: A Literature Review.Brain sciences · 2024Review
- Continuous Dictionary of Nodes Model and Bilinear-Diffusion Representation Learning for Brain Disease Analysis.Brain sciences · 2024Article
- Complex decongestive therapy improves finger tapping score in patients with breast cancer-related lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Longitudinal assessment of chemotherapy-induced brain connectivity changes in cerebral white matter and its correlation with cognitive functioning using the GQI.Frontiers in neurology · 2024Article
- Brain Connectomics Improve the Prediction of High-Risk Depression Profiles in the First Year following Breast Cancer Diagnosis.Depression and anxiety · 2024Article
- Long-term changes of cognitive impairment among older breast cancer survivors.Journal of cancer survivorship : research and practice · 2023Article
- A Drosophila model relevant to chemotherapy-related cognitive impairment.Scientific reports · 2023Article
- Transcranial Magnetic Stimulation for the Treatment of Chemo Brain.Sensors (Basel, Switzerland) · 2023Article
- Article
- Test-Retest Reliability of Resting Brain Small-World Network Properties across Different Data Processing and Modeling Strategies.Brain sciences · 2023Article
- Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Many women with breast cancer, especially those treated with chemotherapy, experience cognitive decline due in part to neurotoxic brain injury. Recent neuroimaging studies suggest widespread brain structural abnormalities pointing to disruption of large-scale brain networks. We applied resting state functional magnetic resonance imaging and graph theoretical analysis to examine the connectome in breast cancer survivors treated with chemotherapy relative to healthy comparison women. Compared to healthy females, the breast cancer group displayed altered global brain network organization characterized by significantly decreased global clustering as well as disrupted regional network characteristics in frontal, striatal and temporal areas. Breast cancer survivors also showed significantly increased self-report of executive function and memory difficulties compared to healthy females. These results suggest that topological organization of both global and regional brain network properties may be disrupted following breast cancer and chemotherapy. This pattern of altered network organization is believed to result in reduced efficiency of parallel information transfer. This is the first report of alterations in large-scale functional brain networks in this population and contributes novel information regarding the neurobiologic mechanisms underlying breast cancer-related cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.