ArticleNeuroscience2012
Optogenetic induction of aversive taste memory.
Article in Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 65 citations in OpenAlex.
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- tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory.bioRxiv : the preprint server for biology · 2023Article
- A Drosophila model relevant to chemotherapy-related cognitive impairment.Scientific reports · 2023Article
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- Innate and Conditioned Taste Processing inCold Spring Harbor protocols · 2023Article
- Measurement of Taste Memory inCold Spring Harbor protocols · 2023Article
- Enhanced olfactory memory detection in trap-design Y-mazes allows the study of imperceptible memory traces inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
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- Idiosyncratic learning performance in flies.Biology letters · 2022Article
- Excessive energy expenditure due to acute physical restraint disrupts Drosophila motivational feeding response.Scientific reports · 2021Article
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- Juvenile hormone drives the maturation of spontaneous mushroom body neural activity and learned behavior.Neuron · 2021Article
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- Review
- A subset of brain neurons controls regurgitation in adultThe Journal of experimental biology · 2019Article
- Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection UsingJournal of experimental neuroscience · 2018Review
- Molecular and Cellular Organization of Taste Neurons in Adult Drosophila Pharynx.Cell reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The Drosophila melanogaster gustatory system consists of several neuronal pathways representing diverse taste modalities. The two predominant modalities are a sweet-sensing pathway that mediates attraction, and a bitter-sensing pathway that mediates avoidance. A central question is how flies integrate stimuli from these pathways and generate the appropriate behavioral response. We have developed a novel assay for induction of taste memories. We demonstrate that the gustatory response to fructose is suppressed when followed by the presence of bitter quinine. We employ optogenetic neural activation using infrared laser in combination with heat-sensitive channel - TRPA1 to precisely activate gustatory neurons. This optogenetic system allows for spatially and temporally controlled activation of distinct neural classes in the gustatory circuit. We directly activated bitter-sensing neurons together with presentation of fructose for remote induction of aversive taste memories. Here we report that activation of bitter-sensing neurons in the proboscis suffices as a conditioning stimulus. Spatially restricted stimulation indicates that the conditioning stimulus is indeed a signal from the bitter neurons in the proboscis and it is independent of postingestive feedback. The coincidence of temporally specific activation of bitter-sensing neurons with fructose presentation is crucial for memory formation, establishing aversive taste learning in Drosophila as associative learning. Taken together, this optogenetic system provides a powerful new tool for interrogation of the central brain circuits that mediate memory formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.