ArticleGenomics2012
CpG island structure and trithorax/polycomb chromatin domains in human cells.
Article in Genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- EZH2 Cooperates with BRD4-NUT to Drive NUT Carcinoma Growth by Silencing Key Tumor Suppressor Genes.Cancer research · 2023Article
- EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes.bioRxiv : the preprint server for biology · 2023Article
- NSD1 mutations deregulate transcription and DNA methylation of bivalent developmental genes in Sotos syndrome.Human molecular genetics · 2022Article
- H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions.Nature communications · 2021Article
- CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness.Genome biology · 2018Article
- A Rare Case of Human Diphallia Associated with Hypospadias.Case reports in urology · 2018Article
- Genome-wide positioning of bivalent mononucleosomes.BMC medical genomics · 2016Article
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- Application of recombinant TAF3 PHD domain instead of anti-H3K4me3 antibody.Epigenetics & chromatin · 2016Article
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- Article
- Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.BMC genomics · 2013Article
- How has the study of the human placenta aided our understanding of partially methylated genes?Epigenomics · 2013Article
- A double take on bivalent promoters.Genes & development · 2013Review
- Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation.Molecular and cellular biology · 2013Article
- The human placenta methylome.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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- Modeling the dynamics of bivalent histone modifications.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy of H3K4me3 and H3K27me3, and these "bivalent" chromatin domains precisely span the boundaries of CpG-island clusters. These relationships are specific to pluripotent stem cells and are not retained at H3K4me3 and H3K27me3 sites unique to differentiated cells. We show that putative transcripts from clustered CpG-islands predict stem-loop structures characteristic of those bound by PcG complexes, consistent with the possibility that RNA facilitates PcG recruitment or maintenance at these sites. These studies suggest that CpG-island structure plays a fundamental role in establishing developmentally important chromatin structures in the pluripotent genome, and a subordinate role in establishing TrxG/PcG chromatin structure at sites unique to differentiated cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.