Evidence map›Paper›PMID 22819821›Full record

ReviewFEBS letters2012

Generating pluripotent stem cells: differential epigenetic changes during cellular reprogramming.

Stacey C Tobin, Kitai Kim

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Drosophila SERTAD domain protein Taranis is required in somatic cells for maintenance of male germline stem cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
  7. Review
  8. Review
  9. Current status in cancer cell reprogramming and its clinical implications.Journal of cancer research and clinical oncology · 2017
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. The future of neuroepigenetics in the human brain.Progress in molecular biology and translational science · 2014
    Review
  16. Article
  17. Review
  18. Long-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents.Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stacey C TobinCancer Biology and Genetics Program, Center for Cell Engineering, Sloan-Kettering Institute, Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Weill Medical College of Cornell University, 1275 York Avenue, Box #484, New York, NY 10065, United States.
Kitai Kim
Cornell University · USKettering University · US

Funding

Hematopoietic potential of histocompatible embryonic stem cell linesR00HL093212 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI KIM, KITAI · 2012 to 2014
$717k
NHLBI NIH HHS 4R00HL093212-03NHLBI NIH HHS R00 HL093212
6 · The paper itself

Abstract

Pluripotent stem cells hold enomous potential for therapuetic applications in tissue replacement therapy. Reprogramming somatic cells from a patient donor to generate pluripotent stem cells involves both ethical concerns inherent in the use of embryonic and oocyte-derived stem cells, as well as issues of histocompatibility. Among the various pluripotent stem cells, induced pluripotent stem cells (iPSC)--derived by ectopic expression of four reprogramming factors in donor somatic cells--are superior in terms of ethical use, histocompatibility, and derivation method. However, iPSC also show genetic and epigenetic differences that limit their differentiation potential, functionality, safety, and potential clinical utility. Here, we discuss the unique characteristics of iPSC and approaches that are being taken to overcome these limitations.

Indexed as

Epigenesis, GeneticAnimalsGenomic ImprintingHumansPluripotent Stem Cells

Identifiers

PMID22819821
PMCPMC3589521
OpenAlexW2087383009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.