Evidence map›Paper›PMID 22819660›Full record

ReviewLancet (London, England)2012

Global epidemiology of HIV infection in men who have sex with men.

Chris Beyrer, Stefan D Baral, Frits van Griensven, Steven M Goodreau, Suwat Chariyalertsak, Andrea L Wirtz, Ron Brookmeyer

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 807 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
807citing papers in PubMed, 9 pooled it
67.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03584282 nacompletednot on this mapstarted 2018, after this paper: background citation

Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users

TypeinterventionalSponsorUniversity of WashingtonRan2018 to 2022Enrolled21ConditionsHIV/AIDS, Adherence, Medication, Drug UseArmsText Messaging, Peer Navigation
NCT05243030 nacompletednot on this mapstarted 2022, after this paper: background citation

Adapting Effective mHealth Interventions to Improve Uptake and Adherence of the HIV Pre-exposure Prophylaxis (PrEP) in Thai Young Men Who Have Sex With Men (MSM).

TypeinterventionalSponsorUniversity of Massachusetts, WorcesterRan2022 to 2025Enrolled119ConditionsPre-Exposure ProphylaxisArmsMotivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP), Motivational Interactive Text Messaging (MTM), Standard PrEP Counseling
3 · Its place in the literature

Who cites it

807 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,603 citations in OpenAlex.

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  13. Incentivizing adherence to pre-exposure prophylaxis for HIV prevention: a randomized pilot trial among male sex workers in Mexico.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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747 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Chris BeyrerCenter for Public Health and Human Rights, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. cbeyrer@jhsph.edu
Stefan D Baral
Frits van Griensven
Steven M Goodreau
Suwat Chariyalertsak
Andrea L Wirtz
Ron Brookmeyer
Johns Hopkins University · USChiang Mai University · THGlobal Brain Health Institute · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Bryan Lau · 2012 to 2026
$67.0M
Methods and Data CoreR24HD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI ELLIS, JOHN MARK · 2002 to 2016
$9.3M
Prevention Umbrella for MSM in the AmericasR01AI083060 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI BUCHBINDER, SUSAN · 2009 to 2012
$3.7M
Statistical Methods for Network EpidemiologyR01HD068395 · NICHD · UNIVERSITY OF WASHINGTON · PI MORRIS, WANDA MARTINA · 2011 to 2015
$3.0M
NIAID NIH HHS 1P30AI094189-01A1NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI083060NIAID NIH HHS R01-AI083060NICHD NIH HHS R01 HD068395NICHD NIH HHS R24 HD042828
6 · The paper itself

Abstract

Epidemics of HIV in men who have sex with men (MSM) continue to expand in most countries. We sought to understand the epidemiological drivers of the global epidemic in MSM and why it continues unabated. We did a comprehensive review of available data for HIV prevalence, incidence, risk factors, and the molecular epidemiology of HIV in MSM from 2007 to 2011, and modelled the dynamics of HIV transmission with an agent-based simulation. Our findings show that the high probability of transmission per act through receptive anal intercourse has a central role in explaining the disproportionate disease burden in MSM. HIV can be transmitted through large MSM networks at great speed. Molecular epidemiological data show substantial clustering of HIV infections in MSM networks, and higher rates of dual-variant and multiple-variant HIV infection in MSM than in heterosexual people in the same populations. Prevention strategies that lower biological transmission and acquisition risks, such as approaches based on antiretrovirals, offer promise for controlling the expanding epidemic in MSM, but their potential effectiveness is limited by structural factors that contribute to low health-seeking behaviours in populations of MSM in many parts of the world.

Indexed as

Models, StatisticalGlobal HealthHIV-1HIV InfectionsHomosexuality, MaleHumansIncidenceMalePrevalenceRisk FactorsSexual BehaviorStochastic Processes

Identifiers

PMID22819660
PMCPMC3805037
OpenAlexW2056790245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.