ReviewCurrent opinion in cell biology2012
Cadherin complexity: recent insights into cadherin superfamily function in C. elegans.
Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- F-actin organization excludes E-cadherin from the division furrow to ensure cytokinesis fidelity.Life science alliance · 2026Article
- The expanding roles of adhesion GPCRs in neural circuit assembly.Molecules and cells · 2026Review
- Synaptic Cell Adhesion: A Functional Perspective.Advances in neurobiology · 2026Review
- Nervous system-wide analysis of allScience advances · 2025Article
- The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.Cell reports · 2023Article
- DEC-7/SUSD2, a sushi domain-containing protein, regulates an ultradian behavior mediated by intestinal epithelial CaAmerican journal of physiology. Cell physiology · 2023Article
- High-resolution dynamic mapping of the C. elegans intestinal brush border.Development (Cambridge, England) · 2021Article
- A high-content imaging approach to profileDevelopment (Cambridge, England) · 2019Article
- Mechanisms and in vivo functions of contact inhibition of locomotion.Nature reviews. Molecular cell biology · 2017Review
- Getting to the core of cadherin complex function in Caenorhabditis elegans.F1000Research · 2015Review
- The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.Developmental biology · 2014Article
- Cadherins and their partners in the nematode worm Caenorhabditis elegans.Progress in molecular biology and translational science · 2013Review
- A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.Molecular biology of the cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cadherin superfamily proteins mediate cell-cell adhesion during development. The C. elegans embryo is a powerful system for analyzing how cadherins function in highly stereotyped morphogenetic events. In the embryo, the classical cadherin HMR-1 acts along with the Rac pathway and SAX-7/L1CAM during gastrulation. As adherens junctions mature, PAR complex proteins differentially regulate cadherin complex localization, and SRGP-1/Slit/Robo GAP aids adhesion by promoting membrane bending. Once adherens junctions form, actin is linked to the cell surface via HMP-1/α-catenin, whose actin binding activity is regulated in novel ways. FMI-1/Flamingo and CDH-4/Fat-like regulate axonal morphology of both pioneer and follower neurons. C. elegans thus continues to be useful for uncovering precise functions for cadherin superfamily proteins and their associates in a simple metazoan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.