ArticleJournal of the neurological sciences2012
Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood-brain barrier leakage in rats in vivo.
Article in Journal of the neurological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Lipid levels and the risk of dementia: A dose-response meta-analysis of prospective cohort studies.Annals of clinical and translational neurology · 2022Pooled it
- Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate.Neuropharmacology · 2022Article
- The role of the gut microbiota and nutrition on spatial learning and spatial memory: a mini review based on animal studies.Molecular biology reports · 2022Review
- Opicapone Protects Against Hyperhomocysteinemia-Induced Increase in Blood-Brain Barrier Permeability.Neurotoxicity research · 2021Article
- Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline-A Review.Biomolecules · 2021Review
- Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.Experimental and therapeutic medicine · 2021Article
- Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders.Current neuropharmacology · 2021Review
- The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study.Lipids in health and disease · 2020Article
- The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi'an, China.Lipids in health and disease · 2019Article
- Variability in Total Cholesterol Concentration Is Associated With the Risk of Dementia: A Nationwide Population-Based Cohort Study.Frontiers in neurology · 2019Article
- Relationship of Lipids and Lipid-Lowering Medications With Cognitive Function: The Multi-Ethnic Study of Atherosclerosis.American journal of epidemiology · 2018Article
- Inhibitory Control, Task/Rule Switching, and Cognitive Planning in Vascular Dementia: Are There Any Differences From Vascular Aging?Frontiers in aging neuroscience · 2018Article
- Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer's disease.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- YangXue QingNao Wan and Silibinin Capsules, the Two Chinese Medicines, Attenuate Cognitive Impairment in Aged LDLR (+/-) Golden Syrian Hamsters Involving Protection of Blood Brain Barrier.Frontiers in physiology · 2018Article
- miRNA 933 Expression by Endothelial Cells is Increased by 27-Hydroxycholesterol and is More Prevalent in Plasma from Dementia Patients.Journal of Alzheimer's disease : JAD · 2018Article
- Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol.Journal of neurosurgery · 2017Article
- Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism.Alcoholism, clinical and experimental research · 2016Review
- Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Methamphetamine effects on blood-brain barrier structure and function.Frontiers in neuroscience · 2015Review
- Platelets in the Alzheimer's disease brain: do they play a role in cerebral amyloid angiopathy?Current neurovascular research · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies show that vascular risk factors (e.g. atherosclerosis, diabetes, homocysteine, hypertension or cholesterol) may play a role in the development of Alzheimer's disease. Animal models may help to discover the role of vascular risk factors on cognition. In the present project we treated male Sprague Dawley rats with a diet containing homocysteine (hyperhomocysteinemia) or cholesterol (hypercholesterolemia) for 5 months or exposed the rats to ethanol (20% in drinking water) or a combination of cholesterol+ethanol (mix) for 12 months. Our experiments show that all 3 treatments (homocysteine, cholesterol, ethanol) declined spatial memory in the 8-arm radial maze, reduced the number of cholinergic neurons and induced blood-brain barrier leakage in the cortex. Rats treated with cholesterol also displayed markedly enhanced inflammation in the cortex. Levels of amyloid precursor protein, beta-amyloid((1-42)), as well as tau and phospho-tau 181 were significantly enhanced in the cortex of cholesterol-fed rats. A combination of ethanol and cholesterol did not further potentiate the effects on spatial memory, cholinergic neurons and blood-brain barrier leakage. The data suggest that chronic mild vascular risk factors over months induce small lesions of the brain capillaries in the cortex, which may contribute to the development of vascular dementia or also Alzheimer's disease.
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