ArticleMolecular cell2012
Promoters recognized by forkhead proteins exist for individual 21U-RNAs.
Article in Molecular cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 1 citations in OpenAlex.
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- Dual roles of EGO-1 and RRF-1 in regulating germline exo-RNAi efficiency in Caenorhabditis elegans.EMBO reports · 2025Article
- H3K27me3 expands the epigenetic control of piRNA transcription.Nature structural & molecular biology · 2025Article
- piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation.Nature structural & molecular biology · 2025Article
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- Advances in PIWI-piRNA function in female reproduction in mammals.Acta biochimica et biophysica Sinica · 2024Review
- The Upstream Sequence Transcription Complex dictates nucleosome positioning and promoter accessibility at piRNA genes in the C. elegans germ line.PLoS genetics · 2024Article
- RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes.Current issues in molecular biology · 2023Review
- piRNA-like small RNAs target transposable elements in a Clade IV parasitic nematode.Scientific reports · 2022Article
- Reprogramming the piRNA pathway for multiplexed and transgenerational gene silencing in C. elegans.Nature methods · 2022Article
- Small RNAs in epigenetic inheritance: from mechanisms to trait transmission.FEBS letters · 2021Review
- Structural basis of PETISCO complex assembly during piRNA biogenesis inGenes & development · 2021Article
- pre-piRNA trimming and 2'-O-methylation protect piRNAs from 3' tailing and degradation in C. elegans.Cell reports · 2021Article
- A chromodomain protein mediates heterochromatin-directed piRNA expression.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis.Nature communications · 2021Article
- Article
- An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases.Translational neurodegeneration · 2021Review
- The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.The EMBO journal · 2021Article
- Integrator is recruited to promoter-proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors.The EMBO journal · 2021Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
C. elegans 21U-RNAs are equivalent to the piRNAs discovered in other metazoans and have important roles in gametogenesis and transposon control. The biogenesis and molecular function of 21U-RNAs and piRNAs are poorly understood. Here, we demonstrate that transcription of each 21U-RNA is regulated separately through a conserved upstream DNA motif. We use genomic analysis to show that this motif is associated with low nucleosome occupancy, a characteristic of many promoters that drive expression of protein-coding genes, and that RNA polymerase II is localized to this nucleosome-depleted region. We establish that the most conserved 8-mer sequence in the upstream region of 21U-RNAs, CTGTTTCA, is absolutely required for their individual expression. Furthermore, we demonstrate that the 8-mer is specifically recognized by Forkhead family (FKH) transcription factors and that 21U-RNA expression is diminished in several FKH mutants. Our results suggest that thousands of small noncoding transcription units are regulated by FKH proteins.
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