ReviewRheumatic diseases clinics of North America2012
Environmental and gene-environment interactions and risk of rheumatoid arthritis.
Review in Rheumatic diseases clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis.Nutrients · 2022Pooled it
- The Efficacy of Moxibustion on the Serum Levels of CXCL1 andPain research & managementTrial
- Article
- Environmental and occupational contributors to autoimmune, inflammatory, and musculoskeletal rheumatic disease: a review of emerging evidence and clinical implications.Current opinion in rheumatology · 2026Review
- Quality of Life in Long-Standing Rheumatoid Arthritis: What Can Help Apart from Treatment? A Single-Center Cross-Sectional Observational Study.Journal of clinical medicine · 2025Article
- Biological mechanisms of pulmonary inflammation and its association with seropositive rheumatoid arthritis.Frontiers in immunology · 2025Review
- Impact of seasonal cycle on rheumatoid arthritis based on genetic and epigenetic mechanisms.Frontiers in immunology · 2025Review
- Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis.Nature reviews. Rheumatology · 2024Review
- Does the Change of Weather Influence Disease Activity in Rheumatoid Arthritis Patients: Patients' Self-Assessment via WebApp.Journal of clinical medicine · 2024Article
- Exposure to air pollutants and rheumatoid arthritis biomarkers: A scoping review.Seminars in arthritis and rheumatism · 2024Article
- Article
- Rheumatoid arthritis and the intestinal microbiome: probiotics as a potential therapy.Frontiers in immunology · 2024Review
- Efficient gene-environment interaction testing through bootstrap aggregating.Scientific reports · 2023Article
- Association of HMGCR inhibition with rheumatoid arthritis: a Mendelian randomization and colocalization study.Frontiers in endocrinology · 2023Article
- From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis.Nature reviews. Rheumatology · 2022Review
- Evaluation of tree-based statistical learning methods for constructing genetic risk scores.BMC bioinformatics · 2022Article
- Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis.Frontiers in immunology · 2022Review
- Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Lifestyle Factors and Genetic Risk Scores.Frontiers in immunology · 2022Article
- Association among B lymphocyte subset and rheumatoid arthritis in a Chinese population.Journal of orthopaedic surgery and research · 2021Article
- Humoral Response to Microbial Biomarkers in Rheumatoid Arthritis Patients.Journal of clinical medicine · 2021Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Multiple environmental factors including hormones, dietary factors, infections, and exposure to tobacco smoke, as well as gene-environment interactions, have been associated with increased risk for rheumatoid arthritis (RA). The growing understanding of the prolonged period before the first onset of symptoms of RA suggests that these environmental and genetic factors are likely acting to drive the development of RA-related autoimmunity long before the appearance of the first joint symptoms and clinical findings that are characteristic of RA. This article reviews these factors and interactions, especially those that have been investigated in a prospective fashion before the symptomatic onset of RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.