ArticleTrends in parasitology2012
Autophagy in Apicomplexa: a life sustaining death mechanism?
Article in Trends in parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Regulation of phosphoinositide metabolism in Apicomplexan parasites.Frontiers in cell and developmental biology · 2023Review
- An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite.Antimicrobial agents and chemotherapy · 2022Article
- Autophagy in the control and pathogenesis of parasitic infections.Cell & bioscience · 2020Review
- Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate.Parasites & vectors · 2019Article
- The effect of autophagy on the survival and invasive activity of Eimeria tenella sporozoites.Scientific reports · 2019Article
- Characterization of the molecular mechanism of the autophagy-related Atg8-Atg3 protein interaction inThe Journal of biological chemistry · 2018Article
- Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors.Journal of computer-aided molecular design · 2018Article
- Article
- Basal and starvation-induced autophagy mediates parasite survival during intraerythrocytic stages ofCell death discovery · 2018Article
- Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite.Cell death & disease · 2015Article
- Review
- Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites.Scientific reports · 2014Article
- "Drug resistance associated membrane proteins".Frontiers in physiology · 2014Article
- Article
- Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.Antimicrobial agents and chemotherapy · 2013Article
- A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.PloS one · 2013Article
- Autophagy in Plasmodium, a multifunctional pathway?Computational and structural biotechnology journal · 2013Review
- Plasmodium falciparum erythrocytic stage parasites require the putative autophagy protein PfAtg7 for normal growth.PloS one · 2013Article
- Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.Journal of structural biology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Programmed cell death (PCD) pathways remain understudied in parasitic protozoa in spite of the fact that they provide potential targets for the development of new therapy. The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidence also points to autophagy as a mediator of death in certain physiological contexts. Bioinformatic analyses coupled with biochemical and cell biological studies suggest that parasitic protozoa possess the capacity for PCD including a primordial form of apoptosis. Recent work in Toxoplasma and emerging data from Plasmodium suggest that autophagy-related processes may serve as an additional death promoting pathway in Apicomplexa. Detailed mechanistic studies into the molecular basis for PCD in parasitic protozoa represent a fertile area for investigation and drug development.
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Registered trials
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