ArticleThe Journal of nutritional biochemistry2013
Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogens.
Article in The Journal of nutritional biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Antibiotic Alternatives and Next-Generation Therapeutics forAntibiotics (Basel, Switzerland) · 2025Review
- Microbes as medicine.Annals of the New York Academy of Sciences · 2024Review
- Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023Review
- Phytochemistry and Pharmacology of Medicinal Plants Used by the Tenggerese Society in Java Island of Indonesia.Molecules (Basel, Switzerland) · 2022Review
- Comparative study of physicochemical, nutritional, phytochemical, and sensory properties of bread with plantain and soy flours partly replacing wheat flour.Food science & nutrition · 2022Article
- Article
- Effect of β-Glucan Supplementation on Growth Performance and Intestinal Epithelium Functions in Weaned Pigs Challenged by EnterotoxigenicAntibiotics (Basel, Switzerland) · 2022Article
- The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease.Frontiers in immunology · 2022Review
- Article
- Increased Dietary Inclusion Levels of Lysine Are More Effective than Arginine in Supporting the Functional Status of the Gut in Growing Turkeys.Animals : an open access journal from MDPI · 2021Article
- Soluble Non-Starch Polysaccharides From Plantain (Frontiers in pharmacology · 2021Article
- Dietary Inflammatory Potential and Risk of Crohn's Disease and Ulcerative Colitis.Gastroenterology · 2020Article
- Development of Salmonellosis as Affected by Bioactive Food Compounds.Microorganisms · 2019Review
- Complementary and Alternative Medicine Strategies for Therapeutic Gut Microbiota Modulation in Inflammatory Bowel Disease and their Next-Generation Approaches.Gastroenterology clinics of North America · 2017Review
- Virulence Characterisation of Salmonella enterica Isolates of Differing Antimicrobial Resistance Recovered from UK Livestock and Imported Meat Samples.Frontiers in microbiology · 2016Article
- High School Diet and Risk of Crohn's Disease and Ulcerative Colitis.Inflammatory bowel diseases · 2015Article
- Review article: dietary fibre-microbiota interactions.Alimentary pharmacology & therapeutics · 2015Review
- Recent advances in adherence and invasion of pathogenic Escherichia coli.Current opinion in infectious diseases · 2014Review
- Article
- Cost-benefit relation of diet and probiotics in iatrogenic bowel irregularity (IBI).Frontiers in pharmacology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Dietary fibres may have prebiotic effects mediated by promotion of beneficial bacteria. This study explores the possibility that soluble plant fibre may also improve health by inhibiting epithelial adhesion and translocation by pathogenic bacteria. We have focussed on soluble non-starch polysaccharide (NSP) from plantain bananas (Musa spp.) which previous studies showed to be particularly effective at blocking Escherichia coli epithelial adherence. In vitro and ex vivo studies assessed the ability of plantain NSP to inhibit epithelial cell adhesion and invasion of various bacterial pathogens, and to inhibit their translocation through microfold (M)-cells and human Peyer's patches mounted in Ussing chambers. Plantain NSP showed dose-related inhibition of epithelial adhesion and M-cell translocation by a range of pathogens. At 5mg/ml, a concentration readily achievable in the gut lumen, plantain NSP inhibited adhesion to Caco2 cells by Salmonella Typhimurium (85.0 ± 8.2%, P<.01), Shigella sonnei (46.6 ± 29.3%, P<.01), enterotoxigenic E.coli (56.1 ± 23.7%, P<.05) and Clostridium difficile (67.6 ± 12.3%, P<.001), but did not inhibit adhesion by enteropathogenic E.coli. Plantain NSP also inhibited invasion of Caco2 cells by S. Typhimurium (80.2 ± 9.7%) and Sh. sonnei (46.7 ± 13.4%); P<.01. Plantain NSP, 5mg/ml, also inhibited translocation of S. Typhimurium and Sh. sonnei across M-cells by 73.3 ± 5.2% and 46.4 ± 7.7% respectively (P<.05). Similarly, S. Typhimurium translocation across Peyer's patches was reduced 65.9 ± 8.1% by plantain NSP (P<.01). Soluble plantain fibre can block epithelial adhesion and M-cell translocation of intestinal pathogens. This represents an important novel mechanism by which soluble dietary fibres can promote intestinal health and prevent infective diarrhoea.
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Registered trials
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