ReviewSeminars in perinatology2012
Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.
Review in Seminars in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review.Critical care (London, England) · 2019Pooled it
- Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2019Trial
- A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants.Pediatrics · 2013Trial
- Optimising transfusion practices in preterm neonates using gestational age and birth weight-based prediction model: a retrospective cohort study from India.BMJ paediatrics open · 2026Observational
- Rapid Diagnostic Stewardship and Blood Culture Use in a Pediatric Medical Center.JAMA network open · 2025Article
- Management of refined and personalized newborn blood specimen collection.Practical laboratory medicine · 2024Article
- Changes to Blood-Sampling Protocol to Reduce the Sampling Amount in Neonatal Intensive Care Units: A Quality Improvement Project.Journal of clinical medicine · 2023Article
- Implementation Strategies for Baby NINJA (Nephrotoxic Injury Negated by Just-in-Time Action) to Prevent Neonatal Medication-Induced Kidney Injury.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- The Novel Use of Umbilical Cord Blood to Obtain Complete Blood Counts for Critical Neonatal Assessment.Cureus · 2022Article
- Placental transfusion: may the "force" be with the baby.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Sex differences in adult social, cognitive, and affective behavioral deficits following neonatal phlebotomy-induced anemia in mice.Brain and behavior · 2021Article
- Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
- Mercury, lead, and cadmium exposure via red blood cell transfusions in preterm infants.Pediatric research · 2020Article
- Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- To transfuse or not transfuse a premature infant: the new complex question.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- 2016 proceedings of the National Heart, Lung, and Blood Institute's scientific priorities in pediatric transfusion medicine.Transfusion · 2017Article
- Research Opportunities to Improve Neonatal Red Blood Cell Transfusion.Transfusion medicine reviews · 2016Review
- Delayed cord clamping: are we ready to listen to the doctor from 1796?Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Chronic inflammation and iron metabolism.The Journal of pediatrics · 2015Article
- Why do four NICUs using identical RBC transfusion guidelines have different gestational age-adjusted RBC transfusion rates?Journal of perinatology : official journal of the California Perinatal Association · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The development of anemia after birth in very premature, critically ill newborn infants is a universal well-described phenomenon. Although preventing anemia in this population, along with efforts to establish optimal red blood cell (RBC) transfusion and pharmacologic therapy continue to be actively investigated, the present review focuses exclusively on nonpharmacological approaches to the prevention and treatment of neonatal anemia. We begin with an overview of topics relevant to nonpharmacological techniques. These topics include neonatal and fetoplacental hemoglobin levels and blood volumes, clinical and laboratory practices applied in critically ill neonates, and current RBC transfusion practice guidelines. This is followed by a discussion of the most effective and promising nonpharmacological blood conservation strategies and techniques. Fortunately, many of these techniques are feasible in most neonatal intensive care units. When applied together, these techniques are more effective than existing pharmacotherapies in significantly decreasing neonatal RBC transfusions. They include increasing hemoglobin endowment and circulating blood volume at birth; removing less blood for laboratory testing; and optimizing nutrition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.