ReviewWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Heart repair and regeneration: recent insights from zebrafish studies.
Review in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Investigating effects of acute severe hypoxia and p38 MAPK inhibition on boldness and anxiety-like behavior in zebrafish larvae.Frontiers in behavioral neuroscience · 2026Article
- An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart.Nature communications · 2025Article
- The multifaceted nature of endogenous cardiac regeneration.Frontiers in cardiovascular medicine · 2023Review
- Zebrafish as a Model to Study Vascular Elastic Fibers and Associated Pathologies.International journal of molecular sciences · 2022Review
- The Correlation Between Body Mass Index and Computed Tomography Angiography on Vascular Positioning in Anterolateral Thigh Flap Transplantation.Journal of the Belgian Society of Radiology · 2022Article
- Use of Zebrafish Models to Boost Research in Rare Genetic Diseases.International journal of molecular sciences · 2021Review
- The Role of the Epicardium During Heart Development and Repair.Circulation research · 2020Review
- Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium.Nature materials · 2019Article
- Heart Regeneration in Adult Mammals after Myocardial Damage.Acta Cardiologica Sinica · 2018Review
- Micro RNAs are involved in activation of epicardium during zebrafish heart regeneration.Cell death discovery · 2018Article
- MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Review
- Cardiomyocyte proliferation in zebrafish and mammals: lessons for human disease.Cellular and molecular life sciences : CMLS · 2017Review
- More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium.Frontiers in cell and developmental biology · 2017Review
- Recent advancements in understanding endogenous heart regeneration-insights from adult zebrafish and neonatal mice.Seminars in cell & developmental biology · 2016Review
- Cell migration during heart regeneration in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation.Scientific reports · 2016Article
- Regeneration versus scarring in vertebrate appendages and heart.The Journal of pathology · 2016Review
- Non-coding RNAs in cardiac regeneration.Oncotarget · 2015Review
- Generation of cardiac progenitor cells through epicardial to mesenchymal transition.Journal of molecular medicine (Berlin, Germany) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Cardiovascular disease is the leading cause of death in the U.S. and worldwide. Failure to properly repair or regenerate damaged cardiac tissues after myocardial infarction is a major cause of heart failure. In contrast to humans and other mammals, zebrafish hearts regenerate after substantial injury or tissue damage. Here, we review recent progress in studying zebrafish heart regeneration, addressing the molecular and cellular responses in the three tissue layers of the heart: myocardium, epicardium, and endocardium. We also compare different injury models utilized to study zebrafish heart regeneration and discuss the differences in responses to injury between mammalian and zebrafish hearts. By learning how zebrafish hearts regenerate naturally, we can better design therapeutic strategies for repairing human hearts after myocardial infarction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.