Evidence map›Paper›PMID 22817888›Full record

ArticleCell2012

The dawn of virtual cell biology.

Lydia Freddolino, Saeed Tavazoie

Abstract readComment
In one paragraph

Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Systems biology for molecular life sciences and its impact in biomedicine.Cellular and molecular life sciences : CMLS · 2013
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lydia FreddolinoDepartment of Biochemistry and Molecular Biophysics and Initiative in Systems Biology, Columbia University, 1150 St. Nicholas Avenue, Russ Berrie Pavilion, Room 405A, New York, NY 10032, USA.
Saeed Tavazoie

Funding

Systems biological interrogation of bacterial persistenceR01AI077562 · NIAID · PRINCETON UNIVERSITY · PI TAVAZOIE, SAEED F · 2010 to 2024
$6.4M
Towards a cognitive framework for understanding cellular behaviorDP1ES022578 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TAVAZOIE, SAEED F · 2012 to 2012
$792k
NIAID NIH HHS R01 AI077562NIEHS NIH HHS DP1 ES022578
6 · The paper itself

Abstract

To fulfill systems biology's promise of providing fundamental new insights will require the development of quantitative and predictive models of whole cells. In this issue, Karr et al. present the first integrated and dynamic computational model of a bacterium that accounts for all of its components and their interactions.

Identifiers

PMID22817888
PMCPMC4430847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.