ArticleBMC oral health2012
Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols.
Article in BMC oral health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Preventive effect of probiotics on oral mucositis induced by anticancer therapy: a systematic review and meta-analysis of randomized controlled trials.BMC oral health · 2024Pooled it
- Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: a systematic review.Systematic reviews · 2024Pooled it
- Gold nanoparticles as innovative therapeutics for oral mucositis: A review of current evidence.Drug delivery and translational research · 2025Review
- Metagenomic Profiling of Oral Microbiome Dynamics During Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma Patients.Cancer medicine · 2025Article
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- Probiotics in the management of radiation-induced oral mucositis.Frontiers in cellular and infection microbiology · 2024Review
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- Delivery of biologics: Topical administration.Biomaterials · 2023Review
- Salivary IgA as a Surrogate Biomarker for Microbial Infections in Postoperative Patients Receiving Chemo-Radio-Therapy for Head and Neck Cancer.Journal of laboratory physicians · 2023Article
- Risk Factors and Role of Antibiotic Prophylaxis for Wound Infections after Percutaneous Endoscopic Gastrostomy.Journal of clinical medicine · 2023Article
- Bidirectional Functional Effects ofMicroorganisms · 2022Review
- The FnBPA from methicillin-resistantJournal of oral microbiology · 2022Article
- An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study.BMC oral health · 2021Article
- Healthcare-associated infections among patients hospitalized for cancers of the lip, oral cavity and pharynx.Infection prevention in practice · 2021Article
- Treatment for Oral Mucositis-Current Options and an Update of Small Molecules Under Development.Current treatment options in oncology · 2021Review
- Respiratory and pulmonary complications in head and neck cancer patients: Evidence-based review for the COVID-19 era.Head & neck · 2020Review
- Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles.International journal of molecular sciences · 2020Article
- Beneficial Biological Activities ofBiomedicines · 2020Review
- Increased risk of tuberculosis in oral cancer patients in an endemic area: a nationwide population-based study.Clinical oral investigations · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the past decade, advances in cancer treatments have been counterbalanced by a rising number of immunosuppressed patients with a multitude of new risk factors for infection. Hence, the aim of this study was to determine risk factors, infectious pathogens in blood and oral cavity of oral cancer patients undergoing different treatment procedures.
methodsThe present prospective cohort analysis was conducted on the patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, during the period of January 2007 to October 2009. Total 186 patients with squamous cell carcinoma of oral cavity were analyzed in the study. Based on treatment procedures patients were divided into three groups, group I were under radiotherapy, group II under chemotherapy and group III were of radio chemotherapy together. Clinical isolates from blood and oral cavity were identified by following general microbiological, staining and biochemical methods. The absolute neutrophile counts were done by following the standard methods.
resultsPrevalent bacterial pathogens isolated were Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Proteus vulgaris and the fungal pathogens were Candida albicans, Aspergillus fumigatus. The predominant gram negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumonia were isolated from blood of radiotherapy and oral cavity of chemotherapy treated cases respectively. The predominance of gram positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis) were observed in blood of chemotherapy, radio chemotherapy cases and oral cavity of radiotherapy, radio chemotherapy treated cases. Our study also revealed the presence of C. albicans fungi as most significant oral cavity pathogens in radiotherapy and radio chemotherapy cases.
conclusionGram positive bacteria and Gram negative were reported from the blood of all the three groups of patients. Oral mucositis played a significant role in oral cavity infection and make patients more prone to C. albicans infection.
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