ArticleBMC genomics2012
Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio).
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Early impact of domestication on aggressiveness, activity, and stress behaviors in zebrafish (Danio rerio) using mirror test and automated videotracking.Scientific reports · 2024Article
- Captivity induces large and population-dependent brain transcriptomic changes in wild-caught cane toads (Rhinella marina).Molecular ecology · 2022Article
- Brain transcriptome analysis reveals gene expression differences associated with dispersal behaviour between range-front and range-core populations of invasive cane toads in Australia.Molecular ecology · 2022Article
- Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism.Disease models & mechanisms · 2022Article
- Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain.Fish physiology and biochemistry · 2021Article
- Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles.Scientific reports · 2020Article
- Brain transcriptomics of agonistic behaviour in the weakly electric fish Gymnotus omarorum, a wild teleost model of non-breeding aggression.Scientific reports · 2020Article
- Heritable natural variation of light/dark preference in an outbred zebrafish population.Journal of neurogenetics · 2019Article
- An Interrogation of Shared and Unique Copy Number Variants Across Genetically Distinct Zebrafish Strains.Zebrafish · 2019Article
- Article
- Baseline mRNA expression differs widely between common laboratory strains of zebrafish.Scientific reports · 2018Article
- Development of microsatellite markers using next-generation sequencing for the fish Colossoma macropomum.Molecular biology reports · 2018Article
- Lateralized Feeding Behavior is Associated with Asymmetrical Neuroanatomy and Lateralized Gene Expressions in the Brain in Scale-Eating Cichlid Fish.Genome biology and evolution · 2017Article
- Differential gene expression and SNP association between fast- and slow-growing turbot (Scophthalmus maximus).Scientific reports · 2017Article
- Molecular pathways associated with the nutritional programming of plant-based diet acceptance in rainbow trout following an early feeding exposure.BMC genomics · 2016Article
- Alternate Directed Anthropogenic Shifts in Genotype Result in Different Ecological Outcomes in Coho Salmon Oncorhynchus kisutch Fry.PloS one · 2016Article
- Characterizing the neurotranscriptomic states in alternative stress coping styles.BMC genomics · 2015Article
- Review
- Limited sex-biased neural gene expression patterns across strains in Zebrafish (Danio rerio).BMC genomics · 2014Article
- Zebrafish models for translational neuroscience research: from tank to bedside.Trends in neurosciences · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDomesticated animal populations often show profound reductions in predator avoidance and fear-related behavior compared to wild populations. These reductions are remarkably consistent and have been observed in a diverse array of taxa including fish, birds, and mammals. Experiments conducted in common environments indicate that these behavioral differences have a genetic basis. In this study, we quantified differences in fear-related behavior between wild and domesticated zebrafish strains and used microarray analysis to identify genes that may be associated with this variation.
resultsCompared to wild zebrafish, domesticated zebrafish spent more time near the water surface and were more likely to occupy the front of the aquarium nearest a human observer. Microarray analysis of the brain transcriptome identified high levels of population variation in gene expression, with 1,749 genes significantly differentially expressed among populations. Genes that varied among populations belonged to functional categories that included DNA repair, DNA photolyase activity, response to light stimulus, neuron development and axon guidance, cell death, iron-binding, chromatin reorganization, and homeobox genes. Comparatively fewer genes (112) differed between domesticated and wild strains with notable genes including gpr177 (wntless), selenoprotein P1a, synaptophysin and synaptoporin, and acyl-CoA binding domain containing proteins (acbd3 and acbd4).
conclusionsMicroarray analysis identified a large number of genes that differed among zebrafish populations and may underlie behavioral domestication. Comparisons with similar microarray studies of domestication in rainbow trout and canids identified sixteen evolutionarily or functionally related genes that may represent components of shared molecular mechanisms underlying convergent behavioral evolution during vertebrate domestication. However, this conclusion must be tempered by limitations associated with comparisons among microarray studies and the low level of population-level replication inherent to these studies.
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