ArticleACS nano2012
Ordered arrays of native chromatin molecules for high-resolution imaging and analysis.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Chromatin hierarchical branching visualized at the nanoscale by electron microscopy.Nanoscale advances · 2021Article
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- Hydrogel droplet single-cell processing: DNA purification, handling, release, and on-chip linearization.Biomicrofluidics · 2018Article
- Electrophoretic stretching and imaging of single native chromatin fibers in nanoslits.Biomicrofluidics · 2017Article
- Analysis of single nucleic acid molecules in micro- and nano-fluidics.Lab on a chip · 2016Review
- Single molecule and single cell epigenomics.Methods (San Diego, Calif.) · 2015Review
- Toward single-molecule optical mapping of the epigenome.ACS nano · 2014Article
- Elongated unique DNA strand deposition on microstructured substrate by receding meniscus assembly and capillary force.Biomicrofluidics · 2014Article
- Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.Nature nanotechnology · 2013Review
- Micro- and nanofluidic technologies for epigenetic profiling.Biomicrofluidics · 2013Article
- Nanoscale squeezing in elastomeric nanochannels for single chromatin linearization.Nano letters · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Individual chromatin molecules contain valuable genetic and epigenetic information. To date, there have not been reliable techniques available for the controlled stretching and manipulation of individual chromatin fragments for high-resolution imaging and analysis of these molecules. We report the controlled stretching of single chromatin fragments extracted from two different cancerous cell types (M091 and HeLa) characterized through fluorescence microscopy and atomic force microscopy (AFM). Our method combines soft lithography with molecular stretching to form ordered arrays of more than 250,000 individual chromatin fragments immobilized into a beads-on-a-string structure on a solid transparent support. Using fluorescence microscopy and AFM, we verified the presence of histone proteins after the stretching and transfer process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.