ArticleClinical and experimental reproductive medicine2012
Effects of hypoxia inducible factors-1α on autophagy and invasion of trophoblasts.
Article in Clinical and experimental reproductive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Autophagy in the human placenta throughout gestation.PloS one · 2013Trial
- Nanomedicine-Mediated Autophagy Modulation in Placental Impairment Versus Cancers: A Narrative Review.Pharmaceutics · 2026Review
- Revised Two-Stage Model of Preeclampsia Based on Autophagic Dysfunction: A Comprehensive Review.Biomolecules · 2026Review
- Autophagy in PE: Dispute, Role and Potential Target.Cell proliferation · 2025Review
- Autophagy in reproduction and pregnancy-associated diseases.iScience · 2024Review
- Trophoblast Migration with Different Oxygen Levels in a Gel-Patterned Microfluidic System.Micromachines · 2022Article
- Insight of Autophagy in Spontaneous Miscarriage.International journal of biological sciences · 2022Review
- The pathological and therapeutic roles of mesenchymal stem cells in preeclampsia.Frontiers in medicine · 2022Review
- Dysregulated Autophagy Leads to Oxidative Stress and Aberrant Expression of ABC Transporters in Women with Early Miscarriage.Antioxidants (Basel, Switzerland) · 2021Article
- Human placenta-derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function.Journal of cellular physiology · 2021Article
- Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression†.Biology of reproduction · 2021Article
- Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells.Frontiers in oncology · 2021Review
- Autophagy regulates trophoblast invasion by targeting NF-κB activity.Scientific reports · 2020Article
- Disruption of Placental Homeostasis Leads to Preeclampsia.International journal of molecular sciences · 2020Review
- Current Understanding of Autophagy in Pregnancy.International journal of molecular sciences · 2019Review
- Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway.Scientific reports · 2017Article
- Autophagy in the placenta.Obstetrics & gynecology science · 2017Review
- Nutrient starvation affects expression of LC3 family at the feto-maternal interface during murine placentation.The Journal of veterinary medical science · 2015Article
- Oxidative Stress in Placenta: Health and Diseases.BioMed research international · 2015Review
- The role of autophagy in the placenta as a regulator of cell death.Clinical and experimental reproductive medicine · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was undertaken to determine the effect of hypoxia inducible factor (HIF)-1α on the cell death, autophagy, and invasion of trophoblasts.
methodsTo understand the effect of HIF-1α, we inhibited HIF-1α using siRNA under normoxia and hypoxia conditions. Invasion assay and zymography were performed to determine changes in the invasion ability of HIF-1α. Western blotting and immunofluorescence were performed to determine some of the signal events involved in apoptosis and autophagy.
resultsThere was no difference in cell death through the inhibition of HIF-1α expression by siRNA; however, the expression of LC3 and autophagosome formation increased. On the other hand, autophagy was increased, and the invasive ability of trophoblast cells decreased according to the inhibition of HIF-1α expression by siRNA. These experimental results mean that HIF-1α genes regulate the invasive ability of trophoblasts by increasing autophagy.
conclusionThis study contributes important data for understanding the mechanism of early pregnancy implantation and the invasive ability of trophoblasts by defining the relationship between the roles of HIF-1α and autophagy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.