ArticleScientific reports2012
Evolution of cariogenic character in Streptococcus mutans: horizontal transmission of glycosyl hydrolase family 70 genes.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A genome-wide in vivo screen reveals fitness pathways required for streptococcal infective endocarditis.PLoS pathogens · 2026Article
- A genome-widebioRxiv : the preprint server for biology · 2026Article
- Functional role and folding properties of the glucan-binding domain of oral bacterial glucansucrase.FEBS letters · 2025Article
- Bacterial evolution in the oral microbiome: the role of conjugative elements and horizontal gene transfer.Journal of bacteriology · 2025Review
- The findings of glucosyltransferase enzymes derived from oral streptococci.The Japanese dental science review · 2022Review
- Bacterial α-Glucan and Branching Sucrases from GH70 Family: Discovery, Structure-Function Relationship Studies and Engineering.Microorganisms · 2021Review
- Virulence ofJournal of clinical and experimental dentistry · 2020Article
- Recent Progress of Basic Studies of Natural Products and Their Dental Application.Medicines (Basel, Switzerland) · 2018Review
- Molecular and Functional Study of a Branching Sucrase-Like Glucansucrase Reveals an Evolutionary Intermediate between Two Subfamilies of the GH70 Enzymes.Applied and environmental microbiology · 2018Article
- An Update on the Evolution of Glucosyltransferase (Frontiers in microbiology · 2018Article
- Gsy, a novel glucansucrase from Leuconostoc mesenteroides, mediates the formation of cell aggregates in response to oxidative stress.Scientific reports · 2016Article
- Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence.Antimicrobial agents and chemotherapy · 2016Article
- Sucrose- and Fructose-Specific Effects on the Transcriptome of Streptococcus mutans, as Determined by RNA Sequencing.Applied and environmental microbiology · 2016Article
- The well-coordinated linkage between acidogenicity and aciduricity via insoluble glucans on the surface of Streptococcus mutans.Scientific reports · 2015Article
- Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri.Applied and environmental microbiology · 2015Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Acquisition of the ability to produce polysaccharides from sucrose, i.e. the gtf gene encoding glucosyltransferase (GTF), is the key evolutionary event enabling dental biofilm formation by streptococci. To clarify the ancestry of streptococcal GTFs, time of its occurrence, and order of specific events, we investigated the distribution of GTFs among bacteria by phylogenetic analysis of the glycosyl hydrolase family 70 enzymes. We found that streptococcal GTFs were derived from other lactic acid bacteria such as Lactobacillus and Leuconostoc, and propose the following evolutionary model: horizontal gene transfer via transposons occurred when streptococci encountered lactic acid bacteria contained in fermented food. Intra-genomic gene duplication occurred by a secondary selection pressure such as consumption of refined sugar. Our findings concerning this evolution in Streptococcus mutans provide an important background for studies of the relationship between the historical spread of dental caries and anthropological factors.
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