Evidence map›Paper›PMID 22816035›Full record

ReviewViruses2012

Application of live-cell RNA imaging techniques to the study of retroviral RNA trafficking.

Darrin V Bann, Leslie J Parent

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. mRNA Localization to the Endoplasmic Reticulum in Plant Endosperm Cells.International journal of molecular sciences · 2022
    Review
  4. Review
  5. mRNA Localization in Plant Cells.Plant physiology · 2020
    Review
  6. Regulation of autophagy by mitochondrial phospholipids in health and diseases.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Darrin V BannPenn State College of Medicine, Department of Medicine, 500 University Dr., Hershey, PA 17033, USA. dbann@hmc.psu.edu
Leslie J Parent
Pennsylvania State University · US

Funding

Nuclear Trafficking of the Retroviral Gag ProteinR01CA076534 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI PARENT, LESLIE J · 1998 to 2018
$5.2M
Host RNA Processing Factors: Friend or Foe of Oncogenic RetroelementsF30CA165774 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BANN, DARRIN V · 2012 to 2015
$118k
NCI NIH HHS F30 CA165774NCI NIH HHS F30CA165774NCI NIH HHS R01 CA076534NCI NIH HHS R01CA76534
6 · The paper itself

Abstract

Retroviruses produce full-length RNA that serves both as a genomic RNA (gRNA), which is encapsidated into virus particles, and as an mRNA, which directs the synthesis of viral structural proteins. However, we are only beginning to understand the cellular and viral factors that influence trafficking of retroviral RNA and the selection of the RNA for encapsidation or translation. Live cell imaging studies of retroviral RNA trafficking have provided important insight into many aspects of the retrovirus life cycle including transcription dynamics, nuclear export of viral RNA, translational regulation, membrane targeting, and condensation of the gRNA during virion assembly. Here, we review cutting-edge techniques to visualize single RNA molecules in live cells and discuss the application of these systems to studying retroviral RNA trafficking.

Indexed as

Molecular ImagingRNA TransportProtein BindingRetroviridaeRNA-Binding ProteinsRNA, ViralStaining and LabelingRNA-Binding ProteinsRNA, Virallive-cellretrovirusRNA labeling

Identifiers

PMID22816035
PMCPMC3397357
OpenAlexW1967690324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.