ArticlePloS one2012
The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis.Cell structure and function · 2022Article
- Article
- Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression.Journal of cell science · 2019Article
- Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells.Nature communications · 2019Article
- Snf1/AMPK is involved in the mitotic spindle alignment in Saccharomyces cerevisiae.Scientific reports · 2018Article
- PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.Journal of cell science · 2016Article
- Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.Nature communications · 2015Article
- MicroRNA-17 promotes normal ovarian cancer cells to cancer stem cells development via suppression of the LKB1-p53-p21/WAF1 pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Liver kinase B1 regulates the centrosome via PLK1.Cell death & disease · 2014Article
- Targeting the LKB1 tumor suppressor.Current drug targets · 2014Review
- Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancers.Frontiers in physiology · 2014Article
- Birt-Hogg-Dube syndrome is a novel ciliopathy.Human molecular genetics · 2013Article
- Molecular pathways regulating mitotic spindle orientation in animal cells.Development (Cambridge, England) · 2013Review
- Article
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orientation of mitotic spindles plays an integral role in determining the relative positions of daughter cells in a tissue. LKB1 is a tumor suppressor that controls cell polarity, metabolism, and microtubule stability. Here, we show that germline LKB1 mutation in mice impairs spindle orientation in cells of the upper gastrointestinal tract and causes dramatic mislocalization of the LKB1 substrate AMPK in mitotic cells. RNAi of LKB1 causes spindle misorientation in three-dimensional MDCK cell cysts. Maintaining proper spindle orientation, possibly mediated by effects on the downstream kinase AMPK, could be an important tumor suppressor function of LKB1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.