ArticlePloS one2012
HPV genotyping and site of viral integration in cervical cancers in Indian women.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- HPV-ferroptosis related genes as biomarkers to predict the prognosis of cervical cancer.Discover oncology · 2024Article
- HPV DNA Integration at Actionable Cancer-Related Genes Loci in HPV-Associated Carcinomas.Cancers · 2024Article
- Identification of novel genomic hotspots and tumor-relevant genes via comprehensive analysis of HPV integration in Chinese patients of cervical cancer.American journal of cancer research · 2024Article
- Long-read sequencing of oropharyngeal squamous cell carcinoma tumors reveal diverse patterns of high-risk Human Papillomavirus integration.Frontiers in oncology · 2023Article
- Molecular Signatures of Gynecological Cancers: Clinicians Perspective.Indian journal of surgical oncology · 2021Review
- Detection of HPV and Human Chromosome Sites by Dual-Color FluorescenceFrontiers in oncology · 2021Article
- Accurate Detection of HPV Integration Sites in Cervical Cancer Samples Using the Nanopore MinION Sequencer Without Error Correction.Frontiers in genetics · 2020Article
- The precision prevention and therapy of HPV-related cervical cancer: new concepts and clinical implications.Cancer medicine · 2018Review
- High frequency of HPV16 European variant E350G among Mexican women from Sinaloa.The Indian journal of medical research · 2018Article
- HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data.BMC bioinformatics · 2018Article
- Retinoic acid receptor beta promoter methylation and risk of cervical cancer.World journal of virology · 2018Review
- Methylation of the L1 gene and integration of human papillomavirus 16 and 18 in cervical carcinoma and premalignant lesions.Oncology letters · 2018Article
- HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers.Molecular cancer research : MCR · 2018Article
- Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells.Experimental and therapeutic medicine · 2017Article
- RNA extraction method is crucial for human papillomavirus E6/E7 oncogenes detection.Virology journal · 2017Article
- miR-3156-3p is downregulated in HPV-positive cervical cancer and performs as a tumor-suppressive miRNA.Virology journal · 2017Article
- Genomic characterization of viral integration sites in HPV-related cancers.International journal of cancer · 2016Article
- Effect of p53 codon 72 polymorphism on the survival outcome in advanced stage cervical cancer patients in India.The Indian journal of medical research · 2016Article
- The protective role of the -1306C>T functional polymorphism in matrix metalloproteinase-2 gene is associated with cervical cancer: implication of human papillomavirus infection.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Somatic Variations in Cervical Cancers in Indian Patients.PloS one · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent HPV infection plays a major role in cervical cancer. This study was undertaken to identify HPV types in a cohort of Indian women with locally advanced cervical cancer as well as to determine the physical state and/or site of viral integration in the host genome. Pretreatment biopsies (n = 270) from patients were screened for HPV infection by a high throughput HPV genotyping assay based on luminex xMAP technology as well as MY09/11 PCR and SPF1/2 PCR. Overall HPV positivity was observed to be 95%, with HPV16 being most common (63%) followed by infection with HPV18. Integration status of the virus was identified using Amplification of Papillomavirus Oncogene Transcripts (APOT) assay in a subset of samples positive for HPV16 and/or HPV18 (n = 86) and with an adequate follow-up. The data was correlated with clinical outcome of the patients. Integration of the viral genome was observed in 79% of the cases and a preference for integration into the chromosomal loci 1p, 3q, 6q, 11q, 13q and 20q was seen. Clinical data revealed that the physical state of the virus (integrated or episomal) could be an important prognostic marker for cervical cancer.
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Registered trials
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