ArticlePloS one2012
Resolving the stiffening-softening paradox in cell mechanics.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Actin Stress Fibers Response and Adaptation under Stretch.International journal of molecular sciences · 2022Article
- Cell monolayer deformation microscopy reveals mechanical fragility of cell monolayers following EMT.Biophysical journal · 2022Article
- Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch.Scientific reports · 2020Article
- Glassy dynamics in composite biopolymer networks.Soft matter · 2018Article
- Large Amplitude Oscillatory Shear Rheology of Living Fibroblasts: Path-Dependent Steady States.Biophysical journal · 2017Article
- Microfluidic Iterative Mechanical Characteristics (iMECH) Analyzer for Single-Cell Metastatic Identification.Analytical methods : advancing methods and applications · 2017Article
- The Inelastic Hierarchy: Multiscale Biomechanics of Weak Bonds.Biophysical journal · 2016Article
- Photonic sensing of arterial distension.Biomedical optics express · 2016Article
- Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network.The European physical journal. E, Soft matter · 2015Article
- Investigating cell mechanics with atomic force microscopy.Journal of the Royal Society, Interface · 2015Article
- Hydraulic fracture during epithelial stretching.Nature materials · 2015Article
- A biomechanical model for fluidization of cells under dynamic strain.Biophysical journal · 2015Article
- Multicellular aggregates: a model system for tissue rheology.The European physical journal. E, Soft matter · 2013Article
- Strain history dependence of the nonlinear stress response of fibrin and collagen networks.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cell rheology: mush rather than machine.Nature materials · 2013Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite their notorious diversity, biological cells are mechanically well characterized by only a few robust and universal laws. Intriguingly, the law characterizing the nonlinear response to stretch appears self-contradictory. Various cell types have been reported to both stiffen and soften, or "fluidize" upon stretch. Within the classical paradigm of cells as viscoelastic bodies, this constitutes a paradox. PRINCIPAL
findingsOur measurements reveal that minimalistic reconstituted cytoskeletal networks (F-actin/HMM) exhibit a similarly peculiar response. A mathematical model of transiently crosslinked polymer networks, the so-called inelastic glassy wormlike chain (iGwlc) model, can simulate the data and resolve the apparent contradiction. It explains the observations in terms of two antagonistic physical mechanisms, the nonlinear viscoelastic resistance of biopolymers to stretch, and the breaking of weak transient bonds between them.
conclusionsOur results imply that the classical paradigm of cells as viscoelastic bodies has to be replaced by such an inelastic mechanical model.
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