ArticlePloS one2012
Mechanical stretch and PI3K signaling link cell migration and proliferation to coordinate epithelial tubule morphogenesis in the zebrafish pronephros.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Phosphoproteomic analysis reveals the diversity of signaling behind ErbB-inhibitor-induced phenotypes.The FEBS journal · 2025Article
- Collective migration modes in development, tissue repair and cancer.Nature reviews. Molecular cell biology · 2025Review
- Collective cell dynamics and luminal fluid flow in the epididymis: A mechanobiological perspective.Andrology · 2024Review
- (Zebra)fishing for nephrogenesis genes.Tissue barriers · 2024Review
- The zebrafish paralog six2b is required for early proximal pronephros morphogenesis.Scientific reports · 2023Article
- Molecular mechanisms of tubulogenesis revealed in the sea star hydro-vascular organ.Nature communications · 2023Article
- Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development.Journal of developmental biology · 2022Review
- Article
- Size-Dependent Cortical Compaction Induces Metabolic Adaptation in Mesenchymal Stem Cell Aggregates.Tissue engineering. Part A · 2019Article
- Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.Human molecular genetics · 2019Article
- Mind the gap: renal tubule responses to injury and the role of Cxcl12 and Myc.Annals of translational medicine · 2019Article
- Signaling Networks in Epithelial Tube Formation.Cold Spring Harbor perspectives in biology · 2017Review
- A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans.Genetics · 2017Article
- Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency.Scientific reports · 2017Article
- On the role of mechanics in driving mesenchymal-to-epithelial transitions.Seminars in cell & developmental biology · 2017Review
- Pronephric tubule formation in zebrafish: morphogenesis and migration.Pediatric nephrology (Berlin, Germany) · 2017Review
- Caudal migration and proliferation of renal progenitors regulates early nephron segment size in zebrafish.Scientific reports · 2016Article
- The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish.Mechanisms of development · 2015Article
- Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells.Biological research · 2015Article
- The bigger the better: determining nephron size in kidney.Pediatric nephrology (Berlin, Germany) · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Organ development leads to the emergence of organ function, which in turn can impact developmental processes. Here we show that fluid flow-induced collective epithelial migration during kidney nephron morphogenesis induces cell stretch that in turn signals epithelial proliferation. Increased cell proliferation was dependent on PI3K signaling. Inhibiting epithelial proliferation by blocking PI3K or CDK4/Cyclin D1 activity arrested cell migration prematurely and caused a marked overstretching of the distal nephron tubule. Computational modeling of the involved cell processes predicted major morphological and kinetic outcomes observed experimentally under a variety of conditions. Overall, our findings suggest that kidney development is a recursive process where emerging organ function "feeds back" to the developmental program to influence fundamental cellular events such as cell migration and proliferation, thus defining final organ morphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.