Trial reportPloS one2012
Risk factors for preterm birth in an international prospective cohort of nulliparous women.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- Risk factors for premature rupture of membranes in pregnant women: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Prediction and Prevention of Preterm Birth: A Prospective, Randomized Intervention Trial.American journal of perinatology · 2023Trial
- High folic acid supplementation is associated with vaginal bleeding in early pregnancy in a fetal sex-specific manner: findings from two prospective cohort studies.Reproductive health · 2026Article
- Oral, Vaginal, and Placental Microbiota Profiles in Japanese Pregnancies with Preterm Birth and Chronic Abruption-Oligohydramnios Sequence (CAOS): A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Initial and Longitudinal Trajectories in Hemoglobin Levels Predict the Prognosis of Patients With Premature Rupture of Membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- Association between Trichomonas vaginalis infection and spontaneous preterm labour in Lagos, Nigeria: an analytical cross-sectional study.BMC research notes · 2025Article
- Development of a spontaneous preterm birth predictive model using a panel of serum protein biomarkers for early pregnant women: A nested case-control study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Socioeconomic and ethnic disparities in preterm births in an English maternity setting: a population-based study of 1.3 million births.BMC medicine · 2024Article
- Clinical risk factors for preterm birth and evaluating maternal psychology in the postpartum period.World journal of psychiatry · 2024Article
- A Descriptive Analysis of a Popular Pregnancy Forum: Comments on the Developmental Consequences of Cannabis Use on Offspring.Journal of studies on alcohol and drugs · 2024Review
- Article
- Risk Factors of Preterm Delivery in the Lao PDR: Hospital-Based Matched Case-Control Study.Maternal and child health journal · 2023Review
- Article
- Does Maternal Obesity Affect Preterm Birth? Documentary Cohort Study of Preterm in Firstborns-Silesia (Poland).Children (Basel, Switzerland) · 2022Article
- Risk factors for spontaneous preterm birth among healthy nulliparous pregnant women in the Netherlands, a prospective cohort study.Health science reports · 2022Article
- Population-based rates, risk factors and consequences of preterm births in South-Asia and sub-Saharan Africa: A multi-country prospective cohort study.Journal of global health · 2022Article
- Effects of marijuana on reproductive health: preconception and gestational effects.Current opinion in endocrinology, diabetes, and obesity · 2021Review
- Risk assessment of preterm birth through identification and stratification of pregnancies using a real-time scoring algorithm.SAGE open medicine · 2021Article
- Maternal persistent marijuana use and cigarette smoking are independently associated with shorter gestational age.Paediatric and perinatal epidemiology · 2020Article
- Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women.Obstetrics & gynecology science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo identify risk factors for spontaneous preterm birth (birth <37 weeks gestation) with intact membranes (SPTB-IM) and SPTB after prelabour rupture of the membranes (SPTB-PPROM) for nulliparous pregnant women.
designProspective international multicentre cohort.
participants3234 healthy nulliparous women with a singleton pregnancy, follow up was complete in 3184 of participants (98.5%).
resultsOf the 3184 women, 156 (4.9%) had their pregnancy complicated by SPTB; 96 (3.0%) and 60 (1.9%) in the SPTB-IM and SPTB-PPROM categories, respectively. Independent risk factors for SPTB-IM were shorter cervical length, abnormal uterine Doppler flow, use of marijuana pre-pregnancy, lack of overall feeling of well being, being of Caucasian ethnicity, having a mother with diabetes and/or a history of preeclampsia, and a family history of low birth weight babies. Independent risk factors for SPTB-PPROM were shorter cervical length, short stature, participant's not being the first born in the family, longer time to conceive, not waking up at night, hormonal fertility treatment (excluding clomiphene), mild hypertension, family history of recurrent gestational diabetes, and maternal family history of any miscarriage (risk reduction). Low BMI (<20) nearly doubled the risk for SPTB-PPROM (odds ratio 2.64; 95% CI 1.07-6.51). The area under the receiver operating characteristics curve (AUC), after internal validation, was 0.69 for SPTB-IM and 0.79 for SPTB-PPROM.
conclusionThe ability to predict PTB in healthy nulliparous women using clinical characteristics is modest. The dissimilarity of risk factors for SPTB-IM compared with SPTB-PPROM indicates different pathophysiological pathways underlie these distinct phenotypes.
trial registrationACTR.org.au ACTRN12607000551493.
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