Trial reportPloS one2012
Adjusting brain dynamics in schizophrenia by means of perceptual and cognitive training.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on improving cognition in schizophrenia: which is the more commonly used type of training, practice or strategy learning?BMC psychiatry · 2014Pooled it
- Intervention-specific patterns of cortical function plasticity during auditory encoding in people with schizophrenia.Schizophrenia research · 2020Trial
- Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine.Brain : a journal of neurology · 2016Trial
- Auditory Cortical Plasticity Drives Training-Induced Cognitive Changes in Schizophrenia.Schizophrenia bulletin · 2016Trial
- Targeted training modifies oscillatory brain activity in schizophrenia patients.NeuroImage. Clinical · 2015Trial
- Changing facial affect recognition in schizophrenia: effects of training on brain dynamics.NeuroImage. Clinical · 2014Trial
- Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features.Biomarkers in neuropsychiatry · 2020Article
- Magnetoencephalography for Schizophrenia.Neuroimaging clinics of North America · 2020Review
- Visual training program for body dysmorphic disorder: protocol for a novel intervention pilot and feasibility trial.Pilot and feasibility studies · 2018Article
- Mismatch Negativity is a Sensitive and Predictive Biomarker of Perceptual Learning During Auditory Cognitive Training in Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- By our bootstraps: Comparing methods for measuring auditory 40 Hz steady-state neural activity.Psychophysiology · 2017Article
- Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders.Biological psychiatry · 2017Review
- Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophrenia.Schizophrenia research · 2016Article
- High-gamma power changes after cognitive intervention: preliminary results from twenty-one senior adult subjects.Brain and behavior · 2016Article
- Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder.Developmental neuroscience · 2016Article
- Neural correlates of cognitive improvements following cognitive remediation in schizophrenia: a systematic review of randomized trials.Socioaffective neuroscience & psychology · 2016Review
- Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating.Frontiers in human neuroscience · 2016Article
- Neuroimaging biomarkers for early drug development in schizophrenia.Biological psychiatry · 2014Review
- Auditory event-related potentials and α oscillations in the psychosis prodrome: neuronal generator patterns during a novelty oddball task.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2014Article
- Neurobiology of cognitive remediation therapy for schizophrenia: a systematic review.Frontiers in psychiatry · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn a previous report we showed that cognitive training fostering auditory-verbal discrimination and working memory normalized magnetoencephalographic (MEG) M50 gating ratio in schizophrenia patients. The present analysis addressed whether training effects on M50 ratio and task performance are mediated by changes in brain oscillatory activity. Such evidence should improve understanding of the role of oscillatory activity in phenomena such as M50 ratio, the role of dysfunctional oscillatory activity in processing abnormalities in schizophrenia, and mechanisms of action of cognitive training. METHODOLOGY/PRINCIPAL
findingsTime-locked and non-time-locked oscillatory activity was measured together with M50 ratio in a paired-click design before and after a 4-week training of 36 patients randomly assigned to specific cognitive exercises (CE) or standard (comparison) cognitive training (CP). Patient data were compared to those of 15 healthy controls who participated in two MEG measurements 4 weeks apart without training. Training led to more time-locked gamma-band response and more non-time-locked alpha-band desynchronization, moreso after CE than after CP. Only after CE, increased alpha desynchronization was associated with normalized M50 ratio and with improved verbal memory performance. Thus, both types of cognitive training normalized gamma activity, associated with improved stimulus encoding. More targeted training of auditory-verbal discrimination and memory additionally normalized alpha desynchronization, associated with improved elaborative processing. The latter presumably contributes to improved auditory gating and cognitive function. CONCLUSIONS/SIGNIFICANCE: Results suggest that dysfunctional interplay of ocillatory activity that may contribute to auditory processing disruption in schizophrenia can be modified by targeted training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.