Trial reportPloS one2012
The sedative effect of non-alcoholic beer in healthy female nurses.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Bioactive compounds in fermented foods: a systematic narrative review.Frontiers in nutrition · 2025Pooled it
- Interventions to improve the sleep of nurses: A systematic review.Research in nursing & health · 2023Pooled it
- Effectiveness of sleep interventions for rotating night shift workers: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Glucose circadian rhythm assessment in pregnant women for gestational diabetes screening.International journal of obesity (2005) · 2025Article
- Allergenic Potential of Common Hops (Nutrients · 2024Article
- Hops across Continents: Exploring How Terroir Transforms the Aromatic Profiles of Five Hop (Plants (Basel, Switzerland) · 2024Article
- Optimization of Antifungal Properties of Hop Cone Carbon Dioxide Extracts Based on Response Surface Methodology.Molecules (Basel, Switzerland) · 2024Article
- Article
- Review
- Medicinal Plants Used for Anxiety, Depression, or Stress Treatment: An Update.Molecules (Basel, Switzerland) · 2022Review
- Effect of non-alcoholic beer containing matured hop bitter acids on mood states in healthy adults: A single-arm pilot study.Nursing & health sciences · 2022Article
- Production, Consumption, and Potential Public Health Impact of Low- and No-Alcohol Products: Results of a Scoping Review.Nutrients · 2021Article
- Article
- Humulone Modulation of GABAFrontiers in neuroscience · 2020Article
- Determination of the structural, electronic, optoelectronic and thermodynamic properties of the methylxanthine molecules theophylline and theobromine.Optical and quantum electronics · 2020Article
- Ethanol and Methanol Concentration in Commonly Used Brands of Ma-al-shaeer in Iran: Estimation of Dietary Intakes and Risk Assessment.Journal of pharmacopuncture · 2018Article
- The Commercial Determinants of Nonalcoholic Beer: Redemption, Revenue, or Men's Harm Reduction?American journal of men's healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe hop (Humulus lupulus L.), a component of beer, is a sedative plant whose pharmacological activity is principally due to its bitter resins, in particular to the α-acid degradation product 2-methyl-3-buten-2-ol. The mechanism of action of hop resin consists of raising the levels of the neurotransmitter γ-aminobutyric acid (GABA), an inhibitory neurotransmitter acting in the central nervous system (CNS).
objectivesTo analyze the sedative effect of hops as a component of non-alcoholic beer on the sleep/wake rhythm in a work-stressed population.
methodsThe experiment was conducted with healthy female nurses (n = 17) working rotating and/or night shifts. Overnight sleep and chronobiological parameters were assessed by actigraphy (Actiwatch®) after moderate ingestion of non-alcoholic beer containing hops (333 ml with 0.0% alcohol) with supper for 14 days (treatment). Data were obtained in comparison with her own control group without consumption of beer during supper.
resultsActigraphy results demonstrated improvement of night sleep quality as regards the most important parameters: Sleep Latency diminished (p≤0.05) in the Treatment group (12.01±1.19 min) when compared to the Control group (20.50±4.21 min), as also did Total Activity (p≤0.05; Treatment group = 5284.78±836.99 activity pulses vs Control = 7258.78±898.89 activity pulses). In addition, anxiety as indexed by the State-Trait Anxiety Inventory (STAI) decreased in the Treatment group (State Anxiety 18.09±3.8 vs Control 20.69±2.14).
conclusionThe moderate consumption of non-alcoholic beer will favour night-time rest, due in particular to its hop components, in addition to its other confirmed benefits for the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.