ArticlePloS one2012
Characterization of influenza hemagglutinin interactions with receptor by NMR.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
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- Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions.Computational and structural biotechnology journal · 2021Article
- Force Spectroscopy Shows Dynamic Binding of Influenza Hemagglutinin and Neuraminidase to Sialic Acid.Biophysical journal · 2019Article
- Time-Frequency Approach Applied to Finding Interaction Regions in Pathogenic Proteins.Bioinformatics and biology insights · 2019Article
- Unravelling the Role of O-glycans in Influenza A Virus Infection.Scientific reports · 2018Article
- Anti-Influenza A Viral Butenolide fromViruses · 2018Article
- Probing the metastable state of influenza hemagglutinin.The Journal of biological chemistry · 2017Article
- "Rules of Engagement" of Protein-Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular Modeling.ChemistryOpen · 2016Review
- Application of virus-like particles (VLP) to NMR characterization of viral membrane protein interactions.Journal of biomolecular NMR · 2016Article
- Molecular modeling of methyl-α-Neu5Ac analogues docked against cholera toxin--a molecular dynamics study.Glycoconjugate journal · 2015Article
- Comparison of the sensitivities of WaterLOGSY and saturation transfer difference NMR experiments.Journal of biomolecular NMR · 2014Article
- New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion.Journal of virology · 2014Article
- Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.PloS one · 2014Article
- Effect of oseltamivir carboxylate consumption on emergence of drug-resistant H5N2 avian influenza virus in Mallard ducks.Antimicrobial agents and chemotherapy · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In influenza, the envelope protein hemagglutinin (HA) plays a critical role in viral entry by first binding to sialic acid receptors on the cell surface and subsequently mediating fusion of the viral and target membranes. In this work, the receptor binding properties of influenza A HA from different subtypes (H1 A/California/04/09, H5 A/Vietnam/1205/04, H5 A/bar-headed goose/Qinghai/1A/05, and H9 A/Hong Kong/1073/99) have been characterized by NMR spectroscopy. Using saturation transfer difference (STD) NMR, we find that all HAs bind to the receptor analogs 2,3-sialyllactose and 2,6-sialyllactose, with subtle differences in the binding mode. Using competition STD NMR, we determine the receptor preferences for the HA subtypes. We find that H5-Qinghai and H9-Hong Kong HA bind to both receptor analogs with similar affinity. On the other hand, H1 exhibits a clear preference for 2,6-sialyllactose while H5-Vietnam exhibits a clear preference for 2,3-sialyllactose. Together, these results are interpreted within the context of differences in both the amino acid sequence and structures of HA from the different subtypes in determining receptor preference.
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Registered trials
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