ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Inactivation of basolateral amygdala specifically eliminates palatability-related information in cortical sensory responses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 110 citations in OpenAlex.
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Sensory and palatability coding of taste stimuli in cortex involves dynamic and asymmetric cortico-amygdalar interactions.Journal of neurophysiology · 2026Article
- Gustatory cortex neurons perform reliability-dependent integration of multisensory flavor inputs.Current biology : CB · 2025Article
- Scopolamine infusion in the basolateral amygdala after saccharin intake induces conditioned taste avoidance in rats.Psychopharmacology · 2024Article
- Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Inhibitory Gating of Thalamocortical Inputs onto Rat Gustatory Insular Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Temporal progression along discrete coding states during decision-making in the mouse gustatory cortex.PLoS computational biology · 2023Article
- Coupled Dynamics of Stimulus-Evoked Gustatory Cortical and Basolateral Amygdalar Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Oral thermal processing in the gustatory cortex of awake mice.Chemical senses · 2023Article
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- Necessity and recruitment of cue-specific neuronal ensembles within the basolateral amygdala during appetitive reversal learning.Neurobiology of learning and memory · 2022Article
- LiCl-induced sickness modulates rat gustatory cortical responses.PLoS biology · 2022Article
- Distinct Progressions of Neuronal Activity Changes Underlie the Formation and Consolidation of a Gustatory Associative Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.Neuron · 2021Review
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- Cortical Hub for Flavor Sensation in Rodents.Frontiers in systems neuroscience · 2021Review
- Bad food memories? It is just a matter of time.The Journal of physiology · 2020Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Evidence indirectly implicates the amygdala as the primary processor of emotional information used by cortex to drive appropriate behavioral responses to stimuli. Taste provides an ideal system with which to test this hypothesis directly, as neurons in both basolateral amygdala (BLA) and gustatory cortex (GC)-anatomically interconnected nodes of the gustatory system-code the emotional valence of taste stimuli (i.e., palatability), in firing rate responses that progress similarly through "epochs." The fact that palatability-related firing appears one epoch earlier in BLA than GC is broadly consistent with the hypothesis that such information may propagate from the former to the latter. Here, we provide evidence supporting this hypothesis, assaying taste responses in small GC single-neuron ensembles before, during, and after temporarily inactivating BLA in awake rats. BLA inactivation (BLAx) changed responses in 98% of taste-responsive GC neurons, altering the entirety of every taste response in many neurons. Most changes involved reductions in firing rate, but regardless of the direction of change, the effect of BLAx was epoch-specific: while firing rates were changed, the taste specificity of responses remained stable; information about taste palatability, however, which normally resides in the "Late" epoch, was reduced in magnitude across the entire GC sample and outright eliminated in most neurons. Only in the specific minority of neurons for which BLAx enhanced responses did palatability specificity survive undiminished. Our data therefore provide direct evidence that BLA is a necessary component of GC gustatory processing, and that cortical palatability processing in particular is, in part, a function of BLA activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.