ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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Who cites it
63 citing papers in PubMed, 148 citations in OpenAlex.
- Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea.American journal of respiratory cell and molecular biology · 2026Review
- Serum Amino Acid and Fatty Acid Metabolites as Predictors of Sleep Disorders in Children: A Risk Prediction Model.Biomedicines · 2026Article
- Sleep Paralysis Among Higher Education Students: A Possible Role of Antidepressant and Recreational Stimulant Use.Medicina (Kaunas, Lithuania) · 2025Article
- Review
- Molecular Pathways Potentially Involved in Hallucinatory Experiences During Sleep Paralysis: The Emerging Role of β-Arrestin-2.International journal of molecular sciences · 2025Review
- Phasic Dopamine Release in the Nucleus Accumbens Influences REM Sleep Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease.Molecular neurodegeneration · 2025Review
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
- Understanding the Patient Experience with Twice-Nightly Sodium Oxybate Therapy for Narcolepsy: A Social Listening Experiment.Brain sciences · 2024Article
- The Kir channel in the nucleus tractus solitarius integrates the chemosensory system with REM sleep executive machinery for homeostatic balance.Scientific reports · 2024Article
- The Persistent Paradox of Rapid Eye Movement Sleep (REMS): Brain Waves and Dreaming.Brain sciences · 2024Review
- Morphological characteristics of cerebellum, pons and thalamus in Reccurent isolated sleep paralysis - A pilot study.Frontiers in neuroanatomy · 2024Article
- Prevalence and Clinical Characteristics of Sleeping Paralysis: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Causal associations between modifiable risk factors and isolated REM sleep behavior disorder: a mendelian randomization study.Frontiers in neurology · 2024Article
- Sertraline-Induced Sleep Paralysis: A Case Report.Cureus · 2023Article
- Awake or Sleeping? Maybe Both… A Review of Sleep-Related Dissociative States.Journal of clinical medicine · 2023Review
- Rapid eye movement sleep behaviour disorder: Past, present, and future.Journal of sleep research · 2022Review
- Ventilatory Drive Withdrawal Rather Than Reduced Genioglossus Compensation as a Mechanism of Obstructive Sleep Apnea in REM Sleep.American journal of respiratory and critical care medicine · 2022Article
- Sleep Disruption and Cancer: Chicken or the Egg?Frontiers in neuroscience · 2022Review
- Neurophysiological Aspects of REM Sleep Behavior Disorder (RBD): A Narrative Review.Brain sciences · 2021Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During REM sleep the CNS is intensely active, but the skeletal motor system is paradoxically forced into a state of muscle paralysis. The mechanisms that trigger REM sleep paralysis are a matter of intense debate. Two competing theories argue that it is caused by either active inhibition or reduced excitation of somatic motoneuron activity. Here, we identify the transmitter and receptor mechanisms that function to silence skeletal muscles during REM sleep. We used behavioral, electrophysiological, receptor pharmacology and neuroanatomical approaches to determine how trigeminal motoneurons and masseter muscles are switched off during REM sleep in rats. We show that a powerful GABA and glycine drive triggers REM paralysis by switching off motoneuron activity. This drive inhibits motoneurons by targeting both metabotropic GABA(B) and ionotropic GABA(A)/glycine receptors. REM paralysis is only reversed when motoneurons are cut off from GABA(B), GABA(A) and glycine receptor-mediated inhibition. Neither metabotropic nor ionotropic receptor mechanisms alone are sufficient for generating REM paralysis. These results demonstrate that multiple receptor mechanisms trigger REM sleep paralysis. Breakdown in normal REM inhibition may underlie common sleep motor pathologies such as REM sleep behavior disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.