ArticleJournal of neurophysiology2012
Comparison of latency and rate coding for the direction of whisker deflection in the subcortical somatosensory pathway.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 41 citations in OpenAlex.
- Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- MULTIPLE DISTINCT TIMESCALES OF RAPID SENSORY ADAPATION IN THE THALAMOCORTICAL CIRCUIT.bioRxiv : the preprint server for biology · 2024Article
- Comparative morphology of the whiskers and faces of mice (Mus musculus) and rats (Rattus norvegicus).The Journal of experimental biology · 2023Article
- Sparse Coding in Temporal Association Cortex Improves Complex Sound Discriminability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Continuous, multidimensional coding of 3D complex tactile stimuli by primary sensory neurons of the vibrissal system.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo.Scientific reports · 2021Article
- Inferring thalamocortical monosynaptic connectivity in vivo.Journal of neurophysiology · 2021Article
- Integrating Non-spiking Interneurons in Spiking Neural Networks.Frontiers in neuroscience · 2021Article
- A High-Dimensional Quantification of Mouse Defensive Behaviors Reveals Enhanced Diversity and Stimulus Specificity.Current biology : CB · 2020Article
- The Cellular and Mechanical Basis for Response Characteristics of Identified Primary Afferents in the Rat Vibrissal System.Current biology : CB · 2020Article
- A system for tracking whisker kinematics and whisker shape in three dimensions.PLoS computational biology · 2020Article
- Activation of Corticothalamic Layer 6 Cells Decreases Angular Tuning in Mouse Barrel Cortex.Frontiers in neural circuits · 2019Article
- Organization of orientation-specific whisker deflection responses in layer 2/3 of mouse somatosensory cortex.Neuroscience · 2018Article
- Thalamic amplification of sensory input in experimental diabetes.The European journal of neuroscience · 2016Article
- Microsecond-scale timing precision in rodent trigeminal primary afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates.The European journal of neuroscience · 2015Article
- Efficient population coding of naturalistic whisker motion in the ventro-posterior medial thalamus based on precise spike timing.Frontiers in neural circuits · 2015Article
- Reading spike timing without a clock: intrinsic decoding of spike trains.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations.Frontiers in neural circuits · 2014Article
- Low-dimensional sensory feature representation by trigeminal primary afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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4 authors at 3 institutions in 2 countries.
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Abstract
The response of many neurons in the whisker somatosensory system depends on the direction in which a whisker is deflected. Although it is known that the spike count conveys information about this parameter, it is not known how important spike timing might be. The aim of this study was to compare neural codes based on spike count and first-spike latency, respectively. We extracellularly recorded single units from either the rat trigeminal ganglion (primary sensory afferents) or ventroposteromedial (VPM) thalamic nucleus in response to deflection in different directions and quantified alternative neural codes using mutual information. We found that neurons were diverse: some (58% in ganglion, 32% in VPM) conveyed information only by spike count; others conveyed additional information by latency. An issue with latency coding is that latency is measured with respect to the time of stimulus onset, a quantity known to the experimenter but not directly to the subject's brain. We found a potential solution using the integrated population activity as an internal timing signal: in this way, 91% of the first-spike latency information could be recovered. Finally, we asked how well direction could be decoded. For large populations, spike count and latency codes performed similarly; for small ones, decoding was more accurate using the latency code. Our findings indicate that whisker deflection direction is more efficiently encoded by spike timing than by spike count. Spike timing decreases the population size necessary for reliable information transmission and may thereby bring significant advantages in both wiring and metabolic efficiency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.