ArticleJournal of neurophysiology2012
Age-dependent adrenergic actions in the main olfactory bulb that could underlie an olfactory-sensitive period.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb.eLife · 2021Article
- Learning-induced mRNA alterations in olfactory bulb mitral cells in neonatal rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation.Frontiers in cellular neuroscience · 2018Article
- The neurobiology of safety and threat learning in infancy.Neurobiology of learning and memory · 2017Review
- β-Adrenoceptor activation enhances L-type calcium channel currents in anterior piriform cortex pyramidal cells of neonatal mice: implication for odor learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Activation of β-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells.Journal of neurophysiology · 2016Article
- Functional differentiation of cholinergic and noradrenergic modulation in a biophysical model of olfactory bulb granule cells.Journal of neurophysiology · 2015Article
- Metabotropic glutamate receptors promote disinhibition of olfactory bulb glomeruli that scales with input strength.Journal of neurophysiology · 2015Article
- Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.Frontiers in cellular neuroscience · 2015Article
- Sparsey™: event recognition via deep hierarchical sparse distributed codes.Frontiers in computational neuroscience · 2014Article
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2 authors.
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Abstract
Many sensory systems are endowed with mechanisms of neural plasticity that are restricted to a sensitive period in the young developing animal. In this study, we performed experiments in slices of the main olfactory bulb (OB) from rats to examine possible age-dependent cellular mechanisms of plasticity in the olfactory system. We focused on the neurotransmitter norepinephrine (NE), shown to be important in different forms of olfactory learning, examining whether two specific cellular effects of NE previously observed in rats less than P14 extended to older animals. These included an acute reduction in GABAergic synaptic transmission from granule cells (GCs) onto output mitral cells (MCs) and an enhancement in gamma frequency (30-70 Hz) oscillations that persists long after removal of NE. We found that NE failed to reduce GC-to-MC transmission or enhance gamma oscillations in older rats at P18-23. The loss of NE actions on both phenomena appeared to reflect an age-dependent loss of function of α(2)-adrenergic receptors. In addition, we found that NE induced an age-dependent enhancement of transient excitation in MCs, providing a mechanism to link the acute decrease in GC-to-MC inhibition to the long-term increase in gamma oscillations through increases in intracellular calcium. The age-dependent cellular mechanisms that we describe could underlie an olfactory-sensitive period in newborn rodents.
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