Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2012
Total sleep deprivation alters cardiovascular reactivity to acute stressors in humans.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Total Sleep Deprivation and Pain Perception during Cold Noxious Stimuli in Humans.Scandinavian journal of pain · 2016Trial
- Sympathetic neural reactivity to mental stress in humans: test-retest reproducibility.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- Role of the ovarian cycle on neural cardiovascular control in sleep-deprived women.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Sleep loss as a cardiometabolic risk factor: a narrative review of clinical and public health implications.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Heart rate and vascular responses to spontaneous arousals following experimental sleep restriction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Habitual sleep duration is associated with heightened muscle sympathetic nerve activation and blood pressure reactivity in response to the cold pressor test.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Sleep and Athletic Performance: A Multidimensional Review of Physiological and Molecular Mechanisms.Journal of clinical medicine · 2025Review
- Acute partial sleep restriction does not impact arterial function in young and healthy humans.Experimental physiology · 2024Article
- Sleep disturbance and sympathetic neural reactivity in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2024Article
- The association between sleep deprivation and arterial pressure variations: a systematic literature review.Sleep medicine: X · 2022Review
- Blunted heart rate recovery to spontaneous nocturnal arousals in short-sleeping adults.American journal of physiology. Heart and circulatory physiology · 2021Article
- Blood pressure, autonomic stress, and inflammatory markers during sleep deprivation and recovery in healthy men.Anatolian journal of cardiology · 2021Article
- Stress, Sleep, and Coping Self-Efficacy in Adolescents.Journal of youth and adolescence · 2021Article
- Cardiac Autonomic Modulation during on-Call Duty under Working Hours Restriction.International journal of environmental research and public health · 2020Article
- Cardiovascular Disease & Cancer Risk Among South Asians: Impact of Sociocultural Influences on Lifestyle and Behavior.Journal of immigrant and minority health · 2019Review
- Disparities in Hypertension Among African-Americans: Implications of Insufficient Sleep.Current hypertension reports · 2018Review
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- Sympathetic neural reactivity to mental stress in offspring of hypertensive parents: 20 years revisited.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Exaggerated cardiovascular reactivity to mental stress (MS) and cold pressor test (CPT) has been linked to increased risk of cardiovascular disease. Recent epidemiological studies identify sleep deprivation as an important risk factor for hypertension, yet the relations between sleep deprivation and cardiovascular reactivity remain equivocal. We hypothesized that 24-h total sleep deprivation (TSD) would augment cardiovascular reactivity to MS and CPT and blunt the MS-induced forearm vasodilation. Because the associations between TSD and hypertension appear to be stronger in women, a secondary aim was to probe for sex differences. Mean arterial pressure (MAP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were recorded during MS and CPT in 28 young, healthy subjects (14 men and 14 women) after normal sleep (NS) and 24-h TSD (randomized, crossover design). Forearm vascular conductance (FVC) was recorded during MS. MAP, FVC, and MSNA (n = 10) responses to MS were not different between NS and TSD (condition × time, P > 0.05). Likewise, MAP and MSNA (n = 6) responses to CPT were not different between NS and TSD (condition × time, P > 0.05). In contrast, increases in HR during both MS and CPT were augmented after TSD (condition × time, P ≤ 0.05), and these augmented HR responses persisted during both recoveries. When analyzed for sex differences, cardiovascular reactivity to MS and CPT was not different between sexes (condition × time × sex, P > 0.05). We conclude that TSD does not significantly alter MAP, MSNA, or forearm vascular responses to MS and CPT. The augmented tachycardia responses during and after both acute stressors provide new insight regarding the emerging links among sleep deprivation, stress, and cardiovascular risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.