ArticleHuman brain mapping2013
Global and regional alterations of hippocampal anatomy in long-term meditation practitioners.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mindfulness related changes in grey matter: a systematic review and meta-analysis.Brain imaging and behavior · 2021Pooled it
- Mindfulness meditation modulates stress-eating and its neural correlates.Scientific reports · 2024Trial
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.Neurobiology of aging · 2023Trial
- Dispositional mindfulness predicts attenuated waking salivary cortisol levels in cancer survivors: a latent growth curve analysis.Journal of cancer survivorship : research and practice · 2015Trial
- Meditation's impact on default mode network and hippocampus in mild cognitive impairment: a pilot study.Neuroscience letters · 2013Trial
- Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.medRxiv : the preprint server for health sciences · 2023Article
- Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes.Brain sciences · 2023Article
- Three potential neurovascular pathways driving the benefits of mindfulness meditation for older adults.Frontiers in aging neuroscience · 2023Review
- A Mini-Review of Work Stress and Mindfulness: A Neuropsychological Point of View.Frontiers in psychology · 2022Review
- High-Dimensional Spatial Quantile Function-on-Scalar Regression.Journal of the American Statistical Association · 2022Article
- Mental and physical training with meditation and aerobic exercise improved mental health and well-being in teachers during the COVID-19 pandemic.Frontiers in human neuroscience · 2022Article
- Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression.Frontiers in psychiatry · 2022Article
- Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Multi-Resemblance Multi-Target Low-Rank Coding for Prediction of Cognitive Decline With Longitudinal Brain Images.IEEE transactions on medical imaging · 2021Article
- Predicting Brain Amyloid Using Multivariate Morphometry Statistics, Sparse Coding, and Correntropy: Validation in 1,101 Individuals From the ADNI and OASIS Databases.Frontiers in neuroscience · 2021Article
- Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology.Frontiers in neuroscience · 2021Article
- Tai Chi Chuan Alters Brain Functional Network Plasticity and Promotes Cognitive Flexibility.Frontiers in psychology · 2021Article
- There Is More to Mindfulness Than Emotion Regulation: A Study on Brain Structural Networks.Frontiers in psychology · 2021Article
- Improved Prediction of Imminent Progression to Clinically Significant Memory Decline Using Surface Multivariate Morphometry Statistics and Sparse Coding.Journal of Alzheimer's disease : JAD · 2021Article
- Sleep and mindfulness meditation as they relate to false memory.Psychological research · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Studies linking meditation and brain structure are still relatively sparse, but the hippocampus is consistently implicated as one of the structures altered in meditation practitioners. To explore hippocampal features in the framework of meditation, we analyzed high-resolution structural magnetic resonance imaging data from 30 long-term meditators and 30 controls, closely matched for sex, age, and handedness. Hippocampal formations were manually traced following established protocols. In addition to calculating left and right hippocampal volumes (global measures), regional variations in surface morphology were determined by measuring radial distances from the hippocampal core to spatially matched surface points (local measures). Left and right hippocampal volumes were larger in meditators than in controls, significantly so for the left hippocampus. The presence and direction of this global effect was confirmed locally by mapping the exact spatial locations of the group differences. Altogether, radial distances were larger in meditators compared to controls, with up to 15% difference. These local effects were observed in several hippocampal regions in the left and right hemisphere though achieved significance primarily in the left hippocampal head. Larger hippocampal dimensions in long-term meditators may constitute part of the underlying neurological substrate for cognitive skills, mental capacities, and/or personal traits associated with the practice of meditation. Alternatively, given that meditation positively affects autonomic regulation and immune activity, altered hippocampal dimensions may be one result of meditation-induced stress reduction. However, given the cross-sectional design, the lack of individual stress measures, and the limited resolution of brain data, the exact underlying neuronal mechanisms remain to be established.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.