ArticleClinical and vaccine immunology : CVI2012
Intestinal and systemic immune development and response to vaccination are unaffected by dietary (1,3/1,6)-β-D-glucan supplementation in neonatal piglets.
Article in Clinical and vaccine immunology : CVI, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Algae β-Glucan Supplementation on the Performance and Intestinal Immune System of Healthy Weaned Piglets.Journal of animal physiology and animal nutrition · 2026Article
- Neonatal and maternal dietary interventions driving microbiota and functionality in piglet gut compartments.Scientific reports · 2025Article
- Using Nutritional Strategies to Shape the Gastro-Intestinal Tracts of Suckling and Weaned Piglets.Animals : an open access journal from MDPI · 2021Review
- Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life.Microorganisms · 2020Article
- Dietary β-glucan supplementation improves growth performance, carcass traits and meat quality of finishing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2019Article
- Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota.Animals : an open access journal from MDPI · 2019Article
- Dietary Human Milk Oligosaccharides but Not Prebiotic Oligosaccharides Increase Circulating Natural Killer Cell and Mesenteric Lymph Node Memory T Cell Populations in Noninfected and Rotavirus-Infected Neonatal Piglets.The Journal of nutrition · 2017Article
- Dietary Alpha-Lipoic Acid Alters Piglet Neurodevelopment.Frontiers in pediatrics · 2016Article
- β(1-3)(1-6)-D-glucans modulate immune status in pigs: potential importance for efficiency of commercial farming.Annals of translational medicine · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infants are susceptible to infections in early life and must rely on their innate immune system for protection. β-Glucans potentiate immune responses. Therefore, we evaluated the influence of purified yeast (1,3/1,6)-β-d-glucan (Wellmune WGP, here referred to as WGP) on the development of the gastrointestinal tract and the intestinal and systemic immune systems in neonatal piglets. Piglets were fed formula containing 0 (control), 1.8, 18, or 90 mg WGP/kg body weight (BW) and were vaccinated against human influenza. Piglets were euthanized at 7 or 21 days of age. Piglet weight and small intestinal length and weight were unaffected by dietary WGP. In addition, WGP did not affect ileal crypt depth, villus height, or ascending colon cuff depth. Immune parameters not affected by WGP supplementation included T cell phenotypes, cytokine gene expression, and cell proliferation. However, vaccination and developmental effects were seen. Overall, the doses of 1.8, 18, and 90 mg/kg BW of dietary WGP had no effect on intestinal or immune development and did not improve the antibody response to vaccination in neonatal piglets.
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