ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- CyberKnife in Pediatric Oncology: A Narrative Review of Treatment Approaches and Outcomes.Current oncology (Toronto, Ont.) · 2025Review
- Pediatric meningiomas: a report of 5 cases and review of literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma.Current oncology (Toronto, Ont.) · 2017Article
- Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.Scientifica · 2014Review
- Clear cell meningioma in a child: A case report and review of literature.Asian journal of neurosurgeryArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial clear cell meningioma (CCM) is very rare and often has an aggressive clinical course. The predilection site of intracranial CCM in children was cerebellopontine angle where represents challenging tumor resection because of the vicinity of brainstem, vertebral artery, and lower cranial nerve. Therefore, special consideration is required for this tumor.We report two cases with intracranial CCM in a family and reviewed the literature concerning pediatric intracranial CCM. Case 1 is a 4-year-old boy with a tumor at the right posterior fossa. Case 2 is an 8-year-old boy with a left basilar region tumor. Gross total resection and subtotal resection was achieved in case 1 and case 2, respectively. Case 1 had no tumor recurrence at 12 months after the operation. Case 2 received cyber-knife radiosurgery (CKS) after subtotal resection at 4 months, and the residual tumor had gradually shrunk. Comprehensive chromosomal number aberrations in both patients were revealed by array-comparative genomic hybridization, and loss of neurofibromatosis 2 (NF2) gene was the common genetic abnormality in the two patients.To the best of our knowledge, this is the first report concerned two patients with CCM in a family, and the findings in this article suggest that CKS is a safe and effective adjuvant therapy for residual CCM after operation and NF2 gene mutation plays a role in tumorigenesis of pediatric intracranial CCM.
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