SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012
Health-related quality of life in patients with osteoporosis in the absence of vertebral fracture: a systematic review.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Quality of life in postmenopausal women with osteoporosis: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Pooled it
- Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis.Endocrine · 2021Pooled it
- Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Vertebral fractures and self-perceived health in elderly women and men in a population-based cross-sectional study: the Tromsø Study 2007-08.BMC geriatrics · 2013Trial
- Percutaneous vertebroplasty and percutaneous kyphoplasty for osteoporotic vertebral compression fractures: medium- and long-term evaluation of clinical outcomes and affecting factors.BMC musculoskeletal disorders · 2026Article
- Short-Term Exercise Improves Not Only Muscle Strength But Also Lung Capacity, Endurance, and Quality of Life in Postmenopausal Vertebral Osteoporosis.Archives of rheumatology · 2025Article
- How does medication-related osteonecrosis of the jaw (MRONJ) influence the health-related quality of life after surgery?BMC oral health · 2025Article
- Health-Related Quality of Life in Men with Fractures and Fear of Falling in General Population: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Modelling the factors associated with quality of life in women with osteoporosis: A cross-sectional study.Global epidemiology · 2024Article
- Familial Resemblance of Bone Health in Maternal Lineage Pairs and Triads: A Scoping Review.Life (Basel, Switzerland) · 2024Article
- Childhood Family Environment and Osteoporosis in a Population-Based Cohort Study of Middle-to Older-Age Americans.JBMR plus · 2023Article
- Evaluation of the Quality of Life and the Quality of Sleep of postmenopausal osteoporotic women, without evidence of an osteoporotic fracture, who attended an outpatient DXA scan service.Journal of musculoskeletal & neuronal interactions · 2023Article
- Health-Related Quality of Life in Osteoporosis Patients with and without Fractures in Tehran, Iran.Journal of bone metabolism · 2023Article
- Sex-specific bi‑directional association between osteoporosis and depression from the national representative data of South Korea.Scientific reports · 2022Article
- Association between Osteoporotic Vertebral Compression Fractures and Age, Bone Mineral Density, and European Quality of Life-5 Dimensions in Korean Postmenopausal Women: A Nationwide Cross-sectional Observational Study.Clinics in orthopedic surgery · 2021Observational
- Changing epidemiology of lower extremity fractures in adults over a 15-year period - a National Hospital Discharge Registry study.BMC musculoskeletal disorders · 2021Article
- Evaluation of pain, quality of life, and patient satisfaction in parenterally treated patients with postmenopausal osteoporosis.Turkish journal of physical medicine and rehabilitation · 2020Article
- Trends in fracture development of the upper extremity in Germany-a population-based description of the past 15 years.Journal of orthopaedic surgery and research · 2020Article
- Longitudinal assessment of health-related quality of life in osteoporosis: data from the population-based Canadian Multicentre Osteoporosis Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Estimation of Prevalence of Osteoporosis Using OSTA and Its Correlation with Sociodemographic Factors, Disability and Comorbidities.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To review whether osteoporosis in the absence of vertebral fracture (VFX) affects health-related quality of life (HRQoL), a systematic search of the main literature databases for HRQoL in patients with osteoporosis without VFX was undertaken. This was undertaken. This identified 1,327 articles as potentially relevant to the review. After screening of abstracts and reviewing 168 articles in detail, 27 were considered relevant. HRQoL data were extracted and collated into tables and, where possible, were converted into normative scores and further analysed. Data relating to the associations between HRQoL and bone mineral density (BMD) were also collated. Of the 27 articles included, only 5 directly compared osteoporosis without VFX with a control group (BMD T-score > -1.0, without VFX). Extracted raw data from 21 articles demonstrated that patients with osteoporosis without VFX had clinically relevant reductions in role physical, general health, vitality, mental health domains and the mental component summary score, using SF36. Using Qualeffo-41, pain and physical function were worse in these patients. Also, HRQoL was related to upper femur, but not lumbar spine BMD. HRQoL data in patients with osteoporosis without VFX are limited and variable but suggest that HRQoL is adversely affected by osteoporosis in the absence of VFX. The association of lower BMD and worse HRQoL suggests that more attention should be paid to HRQoL in those without VFX. Future studies are needed to investigate HRQoL in patients with osteoporosis in the absence of fracture, controlling for co-morbidities and social and economic status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.