ArticleDocumenta ophthalmologica. Advances in ophthalmology2012
Slowed recovery of human photopic ERG a-wave amplitude following intense bleaches: a slowing of cone pigment regeneration?
Article in Documenta ophthalmologica. Advances in ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Dark adaptation of cone photoreceptor responses is revealed by optoretinography.bioRxiv : the preprint server for biology · 2026Article
- Cone-driven strong flash electroretinograms in healthy adults: Prevalence of negative waveforms.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Visual electrophysiology and "the potential of the potentials".Eye (London, England) · 2023Review
- Human retinal dark adaptation tracked in vivo with the electroretinogram: insights into processes underlying recovery of cone- and rod-mediated vision.The Journal of physiology · 2022Review
- Function of mammalian M-cones depends on the level of CRALBP in Müller cells.The Journal of general physiology · 2021Article
- Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina.The Journal of physiology · 2015Article
- The effect of pre-adapting light intensity on dark adaptation in early age-related macular degeneration.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
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Authors and funding
2 authors.
Funding
Abstract
We have used the post-bleach recovery of the ERG a-wave to estimate the time-course of regeneration of cone pigment, following bleaching exposures far stronger than in a previous study. We recorded the photopic electroretinogram a-wave from two subjects, in response to dim red flashes delivered following 1-min exposures to intensities ranging from 1.1 × 10(4) to 1.3 × 10(5) photopic cd m(-2). The measured response amplitudes were "linearized" to derive estimates of pigment level. These estimated pigment levels were found to increase at an initially linear rate, consistent with a "rate-limited" model of photopigment regeneration. The extracted time-course was similar to that previously reported in densitometric studies of cone pigment regeneration after similarly intense exposures. On the other hand, the rate of regeneration was slower than measured in the same subjects following less intense bleaches. These results are consistent with the notion that cone pigment regeneration is slowed following very strong bleaching exposures, possibly as a result of depletion of a pool of retinoid.
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Registered trials
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