Evidence map›Paper›PMID 22814826›Full record

ArticleEuropean radiology2013

Spectral CT imaging of myocardial infarction: preliminary animal experience.

Li-fang Pang, Huan Zhang, Wei Lu, Wen-jie Yang, Hua Xiao, Wei-qing Xu, Ying Chen, Yan Liu, Yu-lian Bu, Zi-lai Pan and 2 more

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Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Li-fang PangDepartment of Radiology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, No. 197, Ruijin 2nd, Road, Shanghai, 200025, China.
Huan Zhang
Wei Lu
Wen-jie Yang
Hua Xiao
Wei-qing Xu
Ying Chen
Yan Liu
Yu-lian Bu
Zi-lai Pan
Ke-min Chen
Fu-hua Yan
Ruijin Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the capability of spectral CT imaging to detect the different stages and angiogenesis of myocardial infarction (MI).

methodsMI was surgically induced in 40 rabbits that were evenly divided into four stages of MI: 6 h (6H), 3 days (3D), 7 days (7D) and 14 days (14D). Spectral CT was performed at 10 s, 1 min and 3 min after intravenous contrast medium administration. CD31 immunohistochemistry was used for the microvessel density (MVD) measurement. Iodine concentrations in the myocardium were measured and normalised to the aorta as nIC. The relationships between infarcted myocardial nIC and MVD were analysed.

resultsThe nIC of infarct myocardium decreased at 10 s and increased in late-phase CT images. There were significant differences between the 6H and other groups (P ( 6H-3D )  = 0.01, P ( 6H-7D )  = 0.01, P ( 6H-14D )  = 0.00). There was a significant difference in the MVD of infarct myocardium between the two groups except in the 7D and 14D groups (P = 0.08). In the 10-s phase, the nIC of infarct myocardium was negatively correlated with MVD (r = -0.54, P = 0.00), whereas in the late phases, there was a positive correlation between them (r = 0.57, P = 0.00 in the 1-min phase, r = 0.48, P = 0.00 in the 3-min phase).

conclusionSpectral CT imaging of the myocardium can be used to evaluate the different stages and angiogenesis of MI.

Indexed as

AnimalsContrast MediaDisease Models, AnimalImmunohistochemistryMaleMyocardial InfarctionRabbitsTomography, X-Ray ComputedContrast Media

Identifiers

PMID22814826
OpenAlexW1974375444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.